Comparison of various milling technologies for grinding pharmaceutical powders

Nakach, Mostafa; Authelin, Jean‐René; Chamayou, Alain; Dodds, John A.

doi:10.1016/j.minpro.2004.07.039

Cited by 74 publications

(44 citation statements)

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“…Many types of mills are employed in these fields and are ideally suited for wet or dry grinding processes, size reduction and dispersion, and deflocculation in solid-liquid systems [1][2][3]. When a chemical reaction is produced during milling, the process is commonly referred to as mechanochemistry, and the mill device must be considered a reactor.…”

Section: Introductionmentioning

confidence: 99%

Influence of the milling parameters on the mechanical work intensity in planetary mills

et al. 2013

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The formation of ZnSe via a mechanically-induced self-sustaining reaction (MSR) from a Zn/Se mixture showed that only size reduction and mixing of the reactants without product formation occurred during the induction period prior to ignition. Therefore, all mechanical energy supplied by the planetary mill during this time, called the ignition time (t ig ), was used exclusively in the activation of the reactants. This system was chosen to study the dependence of t ig on the main parameters characterising the milling intensity of planetary mills. The variation of the ignition time with the process conditions reflected changes in the mechanical dose rate of the planetary mill. A direct relationship between the inverse of the ignition time and the power of the planetary mill was established, which allows the validation of theoretical models proposed in the literature for the energy transfer in milling devices and the comparison of milling equipment efficiencies.

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Section: Introductionmentioning

confidence: 99%

Influence of the milling parameters on the mechanical work intensity in planetary mills

et al. 2013

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“…melt extrusion [144] and melt granulation [145]. Milling and high shear milling are techniques used to effect mixing, particle size reduction and solid state modifications [146].…”

Section: Role Of Manufacturing Methodsmentioning

confidence: 99%

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

Healy

Worku

Kumar

et al. 2017

Advanced Drug Delivery Reviews

282

189

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a b s t r a c t a r t i c l e i n f oActive pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, affecting the internal energy and enthalpy, and the degree of disorder, affecting the entropy. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. Hence, solid forms of APIs play a vital role in drug discovery and development in the context of optimization of bioavailability, filing intellectual property rights and developing suitable manufacturing methods. In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules.

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“…The cumulative weight passing particle sizes d 20 and d 80 [44,45] are used to evaluate the width of the PSD in mineral processing, and the particle size ratio of d 80 /d 20 is often calculated for the PSD width. The particle sizes d 10 [49,50]. A decrease in these particle size ratios means a narrower PSD.…”

Section: Fuzzy Statistical Process Control Of a Calcite Grinding Plantmentioning

confidence: 99%

Fuzzy Statistical Process Control of a Calcite Grinding Plant Using Total Color Difference Parameter (ΔE)

Uçurum¹

2017

IOSR JEN

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: -Statistical process control (SPC) is one of the important approaches used in quality management.SPC can be applied in plants to obtain good quality and high standard products that have become very popular in many industries. Fuzzy process capability analysis by using X-R control charts gives more realistic results, developed with fuzzy theory. Fuzzy control charts are more sensitive than SPC. Therefore, fuzzy control charts lead to producing better-quality products. In this study, total color difference parameter (ΔE) was studied using fuzzy observation on a calcite grinding plant products. For this purpose, color parameters of the grinding plant products were evaluated using triangular fuzzy number (TFN) and fuzzy process capability indices (PCIs). The results show that the mill plant seems to be under control. Therefore, on a randomly selected sample used in the fuzzy statistical process control work was chosen and other color parameters such as whiteness index (WI), saturation index (SI), hue angle (H), browning index (BI) and yellowness index (YI) and particle size properties, XRF, XRD, FTIR, TGA-DTA and SEM were then determined on the calcite sample.

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Comparison of various milling technologies for grinding pharmaceutical powders

Cited by 74 publications

References 0 publications

Influence of the milling parameters on the mechanical work intensity in planetary mills

Influence of the milling parameters on the mechanical work intensity in planetary mills

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

Fuzzy Statistical Process Control of a Calcite Grinding Plant Using Total Color Difference Parameter (ΔE)

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