Hyperspectral data processing and analysis mainly plays a vital role in detection, identification, discrimination and estimation of earth surface materials. It involves atmospheric correction, dimensionality reduction, endmember extraction, spectral unmixing and classification phases. One of the ultimate aims of hyperspectral data processing and analysis is to achieve high classification accuracy. The classification accuracy of hyperspectral data most probably depends upon image-derived endmembers. Ideally, an endmember is defined as a spectrally unique, idealized and pure signature of a surface material. Extraction of consistent and desired endmember is one of the important criteria to achieve the high accuracy of hyperspectral data classification and spectral unmixing. Several methods, strategies and algorithms are proposed by various researchers to extract the endmembers from hyperspectral imagery. Most of these techniques and algorithms are significantly dependent on user-defined input parameters, and this issue is subjective because there is no standard specificity about these input parameters. This leads to inconsistencies in overall endmember extraction. To resolve the aforementioned problems, systematic, generic, robust and automated mechanism of endmember extraction is required. This chapter gives and highlights the generic approach of endmember extraction with popular algorithm limitations and challenges.