Comparison of vedaprofen and meloxicam in dogs with musculoskeletal pain and inflammation

Abstract

In this randomised, multicentre clinical study, dogs with musculoskeletal pain and inflammation were treated with either vedaprofen or meloxicam administered orally at the recommended dose rates. Clinical examinations were carried out regularly and clinical severity scores assigned. In total, 214 cases (73 acute, 141 chronic) were evaluated. Treatment with vedaprofen and meloxicam was continued for 14 and 17 days, respectively, in the acute cases, and 38 and 39 days in the chronic cases. NSAID treatment resulted in a significant improvement in clinical scores. The overall response to treatment ('responders') at the final clinical examination was 89 per cent and 87 per cent in the acute cases and 72 per cent and 65 per cent in the chronic cases in the vedaprofen and meloxicam groups, respectively. Mild transient gastrointestinal signs were observed in both groups (11 per cent vedaprofen, 12 per cent meloxicam). Adverse effects related to NSAIDs resulted in treatment cessation in 5 per cent of the dogs in each group. Vedaprofen and meloxicam were efficacious in, and well tolerated by, most of the dogs in the study.

Systematic review of the management of canine osteoarthritis

“…Pharmacological agents There were 40 studies of pharmacological agents as symptom-modifying agents, structure-modifying agents, or both (Altman and others 1989a, b, Howell and others 1991, Myers and others 1991, 1999, Rogachefsky and others 1993, Fernandes and others 1995, 1998, Vasseur and others 1995, Carney 1996, Read and others 1996, Yu and others 1996, Jovanovic and others 1997, Budsberg and others 1999, 2007, Manicourt and others 1999, Pelletier and others 1999, 2005, Smith and others 1999, Doig and others 2000, Innes and others 2000, Boileau and others 2002, Lipscomb and others 2002, Nell and others 2002, Hazewinkel and others 2003, Moreau and others 2003, 2006, 2007, Behets and others 2004, El Hajjaji and others 2004, Lajeunesse and others 2004, Pardy and others 2004, Peterson and Keefe 2004, Hanson and others 2006, Karsdal and others 2006, Mastbergen and others 2006, Pollmeier and others 2006, Ryan and others 2006, Brainard and others 2007, Mansa and others 2007). …”

Dose Reduction of Meloxicam in Dogs with Osteoarthritis‐Associated Pain and Impaired Mobility

“…The incidence of adverse events that were probably associated with meloxicam was low (7.6% of dogs) and comparable to previous reports . This study was not powered to look at differences between groups for adverse effects.…”

Evaluating the effects of 14‐day oral vedaprofen and tolfenamic acid treatment on renal function, hematological and biochemical profiles in healthy cats

“…Vedaprofen, an arylpropionic acid derivative, has been described as a preferential COX‐2 inhibitor. It has been approved for use in dogs (Nell et al. , 2002; Hoeijmakers et al.…”