Comparison of Viral Hepatitis-Associated Hepatocellular Carcinoma Due to HBV and HCV - Cohort from Liver Clinics in Pakistan

Munaf, Alvina; Memon, Muhammad Sadik; Kumar, Prasoon; Ahmed, Sultan; Kumar, Maheshwari Bhunesh

doi:10.7314/apjcp.2014.15.18.7563

Cited by 25 publications

(20 citation statements)

References 33 publications

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“…The frequency of HCV is highest in few countries and areas, such as in Europe 25 million cases are HCV positive [17]. In Pakistan, HCV is 5% prevalent [18], whereas 5-9% prevalence is detected in Khyber Pakhtunkhwa province of Pakistan [19] causing liver cancer [20]. HCV-4 is prevalent among Middle East and Africa causing more than 80% of HCV infections and has recently spread to several European countries.…”

Section: Frequency Of Hcv Genotypes and Infectionsmentioning

confidence: 99%

An overview on hepatitis C virus genotypes and its control

Nouroz

Shaheen

Mujtaba

et al. 2015

Egyptian Journal of Medical Human Genetics

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Hepatitis C virus (HCV) is a blood borne, circular and positive single stranded virus with high spread rates. With the passage of time the frequency of HCV is increasing in different parts of the world. HCV is a major cause, which may end in liver cirrhosis and hepatocellular carcinoma. HCV has six main genotypes with many subtypes, which have variable sequence homology with each other. Symptoms can appear anytime from 2 weeks to 6 months, which include jaundice, fatigue, gray-colored stool, joint pain, belly pain, weakness, anorexia, itchy skin and dark urine. Genotyping is more significant for planning of HCV treatment period and helps to cure HCV infections. For the quantification and identification of hepatitis C virus-ribonucleic acid, many molecular techniques are performed; the most significant are HCV ELISA, quantitative HCV-RNA PCR and recombinant immunoblot assay. PCR is the major technique targeting 5 0 untranslated region (UTR). HCV can be transmitted by contaminated blood, ear and nose piercing and contaminated medical instruments. To overcome the rate of HCV, guidance should be provided to make aware the persons about risk factors, transmission and prevention. Discovery and designing of new therapies and vaccines to overcome this disease are the necessity of the present era. Four types of vaccines such as vector vaccines, peptide vaccines, DNA vaccines and recombinant protein vaccines are available in clinical trials.

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Section: Frequency Of Hcv Genotypes and Infectionsmentioning

confidence: 99%

An overview on hepatitis C virus genotypes and its control

Nouroz

Shaheen

Mujtaba

et al. 2015

Egyptian Journal of Medical Human Genetics

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“…Hep-C is the most common etiology in up to 58% patients and hep-B in 25.3% cases [ 13 ]. Results from larger studies ( N ≥ 100) on HCC are conflicting where anti-HCV antibody positivity ranges between 24 and 72.5% while HbsAg positivity varies between 13.1 and 51.2% [ 9 , 26 – 31 ]. This can be attributed to patchy nature of available information, high prevalence of hep-C in certain regions of the country, and lack of national cancer surveillance.…”

Section: Risk Factors and Epidemiologymentioning

confidence: 99%

Hepatocellular Carcinoma in Pakistan: National Trends and Global Perspective

Bhatti

Dar

Waheed

et al. 2016

Gastroenterology Research and Practice

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Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalence rates (>3%) in the world. In the absence of a national cancer registry and screening programs, prevalence of hepatitis and HCC only represents estimates of the real magnitude of this problem. In this review, we present various aspects of HCC in Pakistan, comparing and contrasting it with the global trends in cancer care. There is a general lack of awareness regarding risk factors of HCC in Pakistani population and prevalence of hepatitis C has increased. In addition, less common risk factors are also on a rise. Majority of patients present with advanced HCC and are not eligible for definitive treatment. We have attempted to highlight issues that have a significant bearing on HCC outcome in Pakistan. A set of strategies have been put forth that can potentially help reduce incidence and improve HCC outcome on national level.

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“…Therefore, our subgroup analysis should pay attention to the tendency that high SAC3D1 expression is associated with bad prognosis, not statistical significance. Some studies reported that patients with hepatitis B have better prognosis compared to patients with hepatitis C virus 36 , 37 . The TCGA analysis in Table 3 shows interesting results.…”

Section: Discussionmentioning

confidence: 99%

SAC3D1: a novel prognostic marker in hepatocellular carcinoma

Han

Kim

et al. 2018

Sci Rep

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Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated in hepatocellular carcinoma (HCC). In this study, 3 independent cohorts (GSE10186, n = 80; TCGA, n = 330 and ICGC, n = 237) were used to assess SAC3D1 as a biomarker, which demonstrated SAC3D1 overexpression in HCC tissues when compared to the matched normal tissues. Kaplan-Meier survival analysis also showed that its overexpression was associated with poor prognosis of HCC with good discriminative ability in 3 independent cohorts (GSE10186, P = 0.00469; TCGA, P = 0.0000413 and ICGC, P = 0.0000114). Analysis of the C-indices and AUC values further supported its discriminative ability. Finally, multivariate analysis confirmed its prognostic significance (GSE10186, P = 0.00695; TCGA, P = 0.0000289 and ICGC, P = 0.0000651). These results suggest a potential of SAC3D1 as a biomarker for HCC.

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Comparison of Viral Hepatitis-Associated Hepatocellular Carcinoma Due to HBV and HCV - Cohort from Liver Clinics in Pakistan

Cited by 25 publications

References 33 publications

An overview on hepatitis C virus genotypes and its control

An overview on hepatitis C virus genotypes and its control

Hepatocellular Carcinoma in Pakistan: National Trends and Global Perspective

SAC3D1: a novel prognostic marker in hepatocellular carcinoma

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