Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and release

REPLICAID: replicon vaccines to combat avian infectious diseases

“…However, it was confirmed that the smaller VRPs were infectious and contained replicon RNA. Size differences between wildtype virions and VRPs have been described earlier, demonstrating the structural flexibility of VRPs containing either flavivirus replicon RNA (Khromykh et al, 1998), alphavirus RNA genomes (Barrett et al, 1984;Johnston et al, 1975;Nanda et al, 2009) or coronavirus replicon RNA (L. Tian et al, 2022).…”