Comparison of Visual Outcomes After Variable Spot Scanning Ablation Versus Wavefront-Optimized Myopic LASIK

Khalifa, Mohamed A.; Mossallam, Ehab F; Massoud, Tamer; Shaheen, Mohamed Shafik

doi:10.3928/1081597x-20141218-03

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…However, WFG treatment offered significant advantages in terms of residual refractive error, uncorrected distance acuity, and contrast sensitivity. In another study,25 when comparing the visual outcomes of variable spot scanning ablation versus WFO using the same excimer lasers, both treatments were able to correct myopia safely and effectively and the same visual performance of eyes was recorded in either group. Finally, in another study,24 WFG and WFO LASIK produced similar results in myopic patients.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies23–25 that compared the visual outcomes of WFG versus WFO have evaluated the efficacy, safety, and predictability of both treatments, although Allegretto Wave Eye-Q 400 Hz was used instead of EX500 Excimer laser. In the study by He et al,23 on comparing the clinical outcomes of WFG LASIK versus WFO treatment, both treatments were able to correct myopia safely and effectively.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

Meidani

Tzavara

2016

OPTH

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PurposeThe main aim of this study was to compare the efficacy, safety, and predictability of femtosecond laser-assisted in situ keratomileusis performed by two different laser suites in the treatment of myopia for up to 6 months.MethodsIn this two-site retrospective nonrandomized study, myopic eyes that underwent laser-assisted in situ keratomileusis using IntraLase FS 60 kHz formed group 1 and those using WaveLight FS200 femtosecond laser system formed group 2. Ablation was performed with Visx Star S4 IR and WaveLight EX500 Excimer lasers, respectively, in groups 1 and 2. Both groups were well matched for age, sex, and mean level of preoperative refractive spherical equivalent (MRSE). Uncorrected distance visual acuity, corrected distance visual acuity, and MRSE were evaluated preoperatively and at 1 week, 1 month, and 6 months after treatment.ResultsFifty-six eyes of 28 patients were included in the study. At 6-month follow-up postop, 78.6% of eyes in group 1 and 92.8% of eyes in group 2 achieved an uncorrected distance visual acuity of 20/20 or better (P=0.252). 35.7% and 50% in group 1 and group 2, respectively, gained one line (P=0.179). No eye lost lines of corrected distance visual acuity. Twenty-five eyes in group 1 (92.7%) and 27 eyes in group 2 (96.3%) had MRSE within ±0.5 D in the 6-month follow-up (P>0.999). The mean efficacy index at 6 months was similar in group 1 and group 2 (mean 1.10±0.12 [standard deviation] vs 1.10±0.1) (P=0.799). The mean safety index was similar in group 1 and group 2 (mean 1.10±0.10 [standard deviation] vs 1.10±0.09) (P=0.407). Conclusion: The outcomes were excellent between the two laser suites. There were no significant differences at 6-month follow-up postop between the two laser systems.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

Meidani

Tzavara

2016

OPTH

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“…Thus, lasers such as the Summit excimer laser or Autonomous excimer laser, which have been shown to produce greater surface irregularity during stromal ablation, 39 also trigger greater anterior stromal fibrosis than lasers such as the VISX STAR S4/IR (Abbott Medical Optics, Inc., Santa Ana, CA, USA) or the WaveLight Allegretto Wave Eye-Q (Alcon Laboratories, Inc., Fort Worth, TX, USA) excimer lasers that generate smoother stromal surfaces. 40 …”

Section: Defective Ebm Regenerationmentioning

confidence: 99%

The Corneal Basement Membranes and Stromal Fibrosis

Medeiros

Marino

Santhiago

et al. 2018

Invest. Ophthalmol. Vis. Sci.

109

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PurposeThe purpose of this review was to provide detailed insights into the pathophysiology of myofibroblast-mediated fibrosis (scarring or late haze) after corneal injury, surgery, or infection.MethodLiterature review.ResultsThe epithelium and epithelial basement membrane (EBM) and/or endothelium and Descemet's basement membrane (BM) are commonly disrupted after corneal injuries, surgeries, and infections. Regeneration of these critical regulatory structures relies on the coordinated production of BM components, including laminins, nidogens, perlecan, and collagen type IV by epithelial, endothelial, and keratocyte cells. Whether a cornea, or an area in the cornea, heals with transparency or fibrosis may be determined by whether there is injury to one or both corneal basement membranes (EBM and/or Descemet's BM) and delayed or defective regeneration or replacement of the BM. These opaque myofibroblasts, and the disordered extracellular matrix these cells produce, persist in the stroma until the EBM and/or Descemet's BM is regenerated or replaced.ConclusionsCorneal stromal fibrosis (also termed “stromal scarring” or “late haze”) occurs as a consequence of BM injury and defective regeneration in both the anterior (EBM) and posterior (Descemet's BM) cornea. The resolution of fibrosis and return of stromal transparency depends on reestablished BM structure and function. It is hypothesized that defective regeneration of the EBM or Descemet's BM allows key profibrotic growth factors, including transforming growth factor beta-1 (TGF-β1) and TGF-β2, to penetrate the stroma at sustained levels necessary to drive the development and maintenance of mature opacity-producing myofibroblasts from myofibroblast precursors cells, and studies suggest that perlecan and collagen type IV are the critical components in EBM and Descemet's BM that bind TGF-β1, TGF-β2, platelet-derived growth factor, and possibly other growth factors, and regulate their bioavailability and function during homeostasis and corneal wound healing.

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“…Currently, spot-scanning is the most advanced profiling method. It has a faster frequency, a more uniform laser beam, and a lower central island incidence rate [3]. The Technolas 217z laser platform (Bausch and Lomb, Munich, Germany) setting on tissue-saving profile is the ideal representative of spot-scanning profiling with a spot diameter of 2 mm and a frequency of 100 Hz.…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile

Shi

Sun

et al. 2019

Journal of Ophthalmology

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Purpose. To compare the effects of correcting high myopia using the MEL®90 Triple-A profile LASEK at a 500 Hz pulse rate (Triple-A group) versus the Zyoptix tissue-saving ablations of Technolas 217z laser platform at 100 Hz (TS group). Methods. This retrospective study included 50 eyes in the Triple-A group and 42 eyes in the TS group with manifest refraction spherical equivalent (MRSE) of −6 diopters (D) to −10 D. We compared uncorrected distance visual acuity, MRSE, corrected distance visual acuity, and postoperative complications at 1 month, 3 months, and 6 months. Results. At 6 months after refractive surgery, the efficacy index of Triple-A group was significantly higher than that of the TS group (1.03 ± 0.12 vs 1.00 ± 0.11, P=0.04). The MRSE postoperatively in the Triple-A group was significantly lower than that in the TS group (0.25 ± 0.18 vs 0.38 ± 0.23, P<0.01). The safety indices in the two groups were almost the same after 6 months of surgery (1.03 ± 0.07 vs 1.04 ± 0.11, P=0.63). The proportion of eyes which achieved ±0.13 D was significantly higher in the Triple-A group than that in the TS group at 1 month (80% vs 59.5%, P=0.03), 3 months (82% vs 61.9%, P=0.03) and 6 months (84% vs 64.3%, P=0.03). The changes in refraction 6 months after surgery comparing with 1 month after surgery were 0.12 ± 0.10 D in the Triple-A group and 0.13 ± 0.08 D in the TS group (P=0.56). All (100%) of the patients in the Triple-A group and 50% of the patients in the TS group had a UDVA of 20/16 at 6 months after surgery (P<0.01). The induced spherical aberrations and total HOAs in the Triple-A group were significantly lower than those in the TS group (0.17 ± 0.02 μm vs 0.23 ± 0.02 μm, P<0.01; 0.20 ± 0.04 μm vs 0.39 ± 0.03 μm, P<0.01) at 6 months after surgery. The mean reduced corneal thickness was 113.06 ± 10.5 μm in the Triple-A profile group and 121.43 ± 23.46 μm in the TS group (P=0.02). No patient in either group had haze and high intraocular pressure 6 months after surgery. Conclusion. For treatment of high-myopia patients, the Triple-A profile was more effective, predictable, and accurate than the Zyoptix tissue-saving profile. Meanwhile, the Triple-A profile had less induced spherical aberrations, total HOAs, and cornea ablation depth than the Zyoptix tissue-saving profile. Patients in the Triple-A group with 500 Hz pulse rate treatment achieved superior results. The two surgical procedures were equivalent in terms of safety and stability.

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Comparison of Visual Outcomes After Variable Spot Scanning Ablation Versus Wavefront-Optimized Myopic LASIK

Abstract: Both VSS and WFO treatments showed similar refractive and visual outcomes. Both induced significant positive spherical aberration, significantly more with WFO.

Cited by 9 publications

References 32 publications

Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

The Corneal Basement Membranes and Stromal Fibrosis

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile

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Comparison of Visual Outcomes After Variable Spot Scanning Ablation Versus Wavefront-Optimized Myopic LASIK

Abstract: Both VSS and WFO treatments showed similar refractive and visual outcomes. Both induced significant positive spherical aberration, significantly more with WFO.

Cited by 9 publications

References 32 publications

Comparison of efficacy, safety, and predictability of&nbsp;laser in situ keratomileusis&nbsp;using two laser suites

Comparison of efficacy, safety, and predictability of&nbsp;laser in situ keratomileusis&nbsp;using two laser suites

The Corneal Basement Membranes and Stromal Fibrosis

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile

Contact Info

Product

Resources

About

Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites