Comparison of Vitamin D Replacement Strategies with High-Dose Intramuscular or Oral Cholecalciferol: A Prospective Intervention Study

Masood, Muhammad Qamar; Khan, Aysha Habib; Awan, Safia; Dar, Farhan Javed; Naz, Sabahat; Naureen, Ghazala; Saghir, Shakil A.; Jabbar, Abdul

doi:10.4158/ep15680.or

Cited by 16 publications

(18 citation statements)

References 33 publications

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“…In addition, the present study showed that serum iPTH levels decreased throughout the 6-month period after IM administration of D2 at a dose of 200,000, 400,000 or 600,000 IU. This is in line with previous reports that vitamin D at doses of 50,000 IU orally, 300,000 IU or 600,000 IU intramuscularly reduced serum levels of PTH (16,20,37,38). Decreased iPTH concentration may reduce the synthesis of 1α,25-dihydroxyvitamin D and therefore prevent the increase in the levels of serum calcium.…”

Section: Discussionsupporting

confidence: 92%

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Dai

Sun

et al. 2020

Endocrine Practice

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Section: Discussionsupporting

confidence: 92%

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Dai

Sun

et al. 2020

Endocrine Practice

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“…A single VD doses ≥ 300000 IU are most effective at increasing VD levels[ 41 ]. Although both oral and intramuscular administration routes are effective and safe, intramuscular administration is more effective in increasing VD levels[ 42 , 43 ]. In our study, we used intramuscular cholecalciferol 300000 IU as loading dose and 800 IU/d oral as maintenance dose along with 1000 mg oral calcium supplementation.…”

Section: Discussionmentioning

confidence: 99%

Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis: A prospective study

Jha

Kumar

et al. 2017

WJGP

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AIMTo assess the vitamin D (VD) deficiency as a prognostic factor and effect of replenishment of VD on mortality in decompensated cirrhosis.METHODSPatients with decompensated liver cirrhosis were screened for serum VD levels. A total of 101 VD deficient patients (< 20 ng/mL) were randomly enrolled in two groups: Treatment group (n = 51) and control group (n = 50). Treatment group received VD treatment in the form of intramuscular cholecalciferol 300000 IU as loading dose and 800 IU/d oral as maintenance dose along with 1000 mg oral calcium supplementation. The VD level, clinical parameters and survival of both the groups were compared for 6-mo.RESULTSPrevalence of vitamin D deficiency (VDD) in decompensated CLD was 84.31%. The mean (SD) age of the patients in the treatment group (M:F: 40:11) and control group (M:F: 37:13) were 46.2 (± 14.93) years and 43.28 (± 12.53) years, respectively. Baseline mean (CI) VD (ng/mL) in control group and treatment group were 9.15 (8.35-9.94) and 9.65 (8.63-10.7), respectively. Mean (CI) serum VD level (ng/mL) at 6-mo in control group and treatment group were 9.02 (6.88-11.17) and 29 (23-35), respectively. Over the period of time the VD, calcium and phosphorus level was improved in treatment group compared to control group. There was non-significant trend seen in greater survival (69% vs 64%; P > 0.05) and longer survival (155 d vs 141 d; P > 0.05) in treatment group compared to control group. VD level had no significant association with mortality (P > 0.05). In multivariate analysis, treatment with VD supplement was found significantly (P < 0.05; adjusted hazard ratio: 0.48) associated with survival of the patients over 6-mo.CONCLUSIONVD deficiency is very common in patients of decompensated CLD. Replenishment of VD may improve survival in patients with decompensated liver cirrhosis.

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“…Unlike normal individuals in which vitamin D deficiency is ascribed to reduced sun exposure or intake, patients with CKD have an additional risk factor as kidney is the and have been shown to be effective in increasing circulating 25(OH)D levels [6,7].…”

Section: Introductionmentioning

confidence: 99%

Vascular function and cholecalciferol supplementation in CKD: A self-controlled case series

Kumar

Yadav

Singhal

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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Vitamin D deficiency is common and associated with mortality in chronic kidney disease (CKD) patients. Cardiovascular disease (CVD) is the commonest cause of mortality in CKD patients. In a randomized, double blind, placebo controlled trial, we have recently reported favorable effects of vitamin D supplementation on vascular & endothelial function and inflammatory biomarkers in vitamin D deficient patients with non-diabetic stage 3-4 CKD (J Am Soc Nephrol 28: 3100-3108, 2017). Subjects in the placebo group who had still not received vitamin D after completion of the trial received two oral doses 300,000 IU of oral cholecalciferol at 8 weeks interval followed by flow mediated dilatation (FMD), pulse wave velocity (PWV), circulating endothelial and inflammatory markers (E-Selectin, vWF, hsCRP and IL-6), 125 (OH)D, iPTH and iFGF-23 assessment at 16 weeks. 31 subjects completed this phase of the study. Last values recorded in the preceding clinical trial were taken as baseline values. Serum 25(OH)D and 1,25(OH)D increased and FMD significantly improved after cholecalciferol supplementation [mean change in FMD%: 5.8% (95% CI: 4.0-7.5%, p< 0.001]. Endothelium independent nitroglycerine mediated dilatation, PWV, iPTH, iFGF-23 and IL-6 also showed favorable changes. The data further cement the findings of beneficial effects of correction of vitamin D deficiency on vascular function.

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Comparison of Vitamin D Replacement Strategies with High-Dose Intramuscular or Oral Cholecalciferol: A Prospective Intervention Study

Cited by 16 publications

References 33 publications

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2

Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis: A prospective study

Vascular function and cholecalciferol supplementation in CKD: A self-controlled case series

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