Determination of the Earth’s gravity field and geopotential value is one of the fundamental topics in physical geodesy. Traditional terrestrial gravity and precise leveling measurements can be used to determine the geopotential values at a local or regional scale. However, recent developments in optical atomic clocks have not only rapidly improved fundamental science but also contributed to applied research. The latest generation of optical clocks is approaching the accuracy level of 10−18 when facilitating atomic clock networks. These systems allow examining fundamental theories and many research applications, such as atomic clocks applications in relativistic geodesy, to precisely determine the Earth’s gravity field parameters (e.g., geopotential values). According to the theory of relativistic geodesy, the frequency difference measured by an optical clock network is related to the gravity potential anomaly, provided that the effects of disturbing signals (i.e., tidal and non-tidal contributions) are filtered out. The relativistic geodesy principle could be used for a practical realization of global geodetic infrastructure, most importantly, a vertical datum unification or realization of height systems. This paper aims to review the background of relativistic (clock-based) geodesy and study the variations of optical atomic clock measurements (e.g., due to hydrology loading and land motion).