2020
DOI: 10.3390/jcm9061645
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Comparison of White Blood Cell Scintigraphy, FDG PET/CT and MRI in Suspected Diabetic Foot Infection: Results of a Large Retrospective Multicenter Study

Abstract: Diabetic foot infections (DFIs) represent one of the most frequent and disabling morbidities of longstanding diabetes; therefore, early diagnosis is mandatory. The aim of this multicenter retrospective study was to compare the diagnostic accuracy of white blood cell scintigraphy (WBC), 18F-fluorodeoxyglucose positron emission tomography/computed tomography ((18F) FDG PET/CT), and Magnetic Resonance Imaging (MRI) in patients with suspected DFI. Images and clinical data from 251 patients enrolled by five centers… Show more

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Cited by 34 publications
(43 citation statements)
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“…In accordance with this view, we strongly recommend the use of radiolabelled WBC scintigraphy in suspected pedal OM, as it also emerged from a recently published retrospective multicenter study [89].…”
Section: Can [ 18 F]fdg Pet/ct Be Used As An Alternative To Wbc?supporting
confidence: 52%
See 1 more Smart Citation
“…In accordance with this view, we strongly recommend the use of radiolabelled WBC scintigraphy in suspected pedal OM, as it also emerged from a recently published retrospective multicenter study [89].…”
Section: Can [ 18 F]fdg Pet/ct Be Used As An Alternative To Wbc?supporting
confidence: 52%
“…In accordance with this view, we strongly recommend the use of radiolabelled WBC scintigraphy in suspected pedal OM, as it also emerged from a recently published retrospective multicenter study [ 89 ]. [ 18 F]FDG PET/CT could represent a valid alternative if it is not possible to perform this imaging modality due to the limitations of the single center, but the interpretation of a PET scan, at the moment, really relies on personal experience, and therefore, the scans must be evaluated with caution.…”
Section: Consensus Statements Emerged From Round Table Of 3rd Euromentioning
confidence: 76%
“…The recently published EANM guidelines have definitely clarified all the aspects able to reach a high accuracy in detecting an infection by using this imaging modality [ 15 ]. Indeed, if correctly acquired, displayed and interpreted, planar images allow to accurately differentiation between an infection from a sterile inflammation, as it has also been demonstrated in other clinical scenarios [ 24 ]. However, despite these precautions, some scintigraphies still remain doubtful basing only on visual analysis.…”
Section: Discussionmentioning
confidence: 99%
“…PET-tracers can also be used to label leukocytes. Because labelled leukocytes require 20–24 h to be recruited to infection sites, FDG is not suitable for radiolabeling glucose due to its short half-life [ 56 ].…”
Section: White Blood Cell Cintigraphymentioning
confidence: 99%