Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults

Navazesh, Mahvash; Mulligan, Roseann; Kipnis, Victor; Denny, Patricia A.

doi:10.1177/00220345920710060201

Cited by 118 publications

(88 citation statements)

References 19 publications

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“…One paper has reported higher levels of parotid slgA in aged subjects (Arranz et al, 1992), but this has not been confirmed by others (Ganguly et al, 1986;Aguirre et al, 1987;Fox et al, 1987). Submandibular/sublingual saliva has not been extensively studied, but lower levels of MG1 and MG2 have been reported in healthy non-medicated older adults (Denny et al, 1991;Navazesh et al, 1992). Medication may be the most significant source of salivary changes in older adults.…”

Section: (D) Long-term Changementioning

confidence: 95%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

113

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Salivary protein interactions with oral microbes in vitro include aggregation, adherence, cell-killing, inhibition of metabolism, and nutrition. Such interactions might be expected to influence oral ecology. However, inconsistent results have been obtained from in vivo tests of the hypothesis that quantitative variation in salivary protein concentrations will affect oral disease prevalence. Results may have been influenced by choices made during study design, including saliva source, stimulation status, control for flow rate, and assay methods. Salivary protein concentrations also may be subject to circadian variation. Values for saliva collected at the same time of day tend to remain consistent within subjects, but events such as stress, inflammation, infection, menstruation, or pregnancy may induce short-term changes. Long-term factors such as aging, systemic disease, or medication likewise may influence salivary protein concentrations. Such sources of variation may increase the sample size needed to find statistically significant differences. Clinical studies also must consider factors such as human population variation, strain and species differences in protein-microbe interactions, protein polymorphism, and synergistic or antagonistic interaction between proteins. Salivary proteins may form heterotypic complexes with unique effects, and different proteins may exert redundant effects. Patterns of protein-microbe interaction also may differ between oral sites. Future clinical studies must take those factors into account. Promising approaches might involve meta-analysis or multi-center studies, retrospective and prospective longitudinal designs, short-term measurement of salivary protein effects, and consideration of individual variation in multiple protein effects such as aggregation, adherence, and cell-killing.

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Section: (D) Long-term Changementioning

confidence: 95%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

113

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“…During the demineralization and remineralization that occurs in the caries process, saliva is effective in helping to maintain a neutral pH in the oral cavity. 3 The major regulator of pH is salivary bicarbonate from parotid saliva. 4 Because the concentration of salivary bicarbonate depends on flow rate, the capacity for saliva to act as a buffer will vary directly with saliva flow rate.…”

Section: Introductionmentioning

confidence: 99%

The pH change after HCl titration into resting and stimulated saliva for a buffering capacity test

Moritsuka

Kitasako

Burrow

et al. 2006

Australian Dental Journal

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Background: Saliva collection can provide clinical information about individual patients. However, a correlation between ranking buffering capacity using resting and stimulated saliva is still unknown. The aim of this study was to evaluate the pH change after HCl titration into resting and stimulated saliva for a salivary buffering capacity test. Methods: Resting and stimulated saliva (by chewing paraffin wax) were collected from 80 patients. After the pH of both saliva samples was measured using a hand-held pH meter, the saliva samples were titrated with 0.1N HCl to evaluate the buffering capacity. Correlations of ranking buffering capacity (high, medium, low) between stimulated saliva and resting saliva with 30µL HCl titration and between stimulated saliva and resting saliva with 40µL HCl titration were statistically analysed by Spearman Rank Correlation Test (p<0.05). Results: At 50µL HCl titration, stimulated saliva buffering capacities were ranked into high (above pH 5.5), medium (pH from 5.5 to 4.5) and low (below pH 4.5). At 30-40µL HCl titration, the resting saliva buffering capacities were ranked into the same categories. Spearman Rank Correlation indicated significant positive coefficients for the stimulated saliva and resting saliva buffering capacity at 30µL titration and the stimulated saliva and resting saliva at 40µL titration. Conclusion: Stimulated saliva is more resistant to variation in pH change during HCl titration than resting saliva. Stimulated saliva sampling is a good method to determine buffering capacity during a comprehensive oral health assessment.

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“…4,10-11 Dry mouth condition is usually related to aging, [12][13][14] even though some other studies have not found this correlation. [15][16] It is well established that patients taking medication can also present decreased saliva output, 17 as well as those who have received radiation therapy for neck and head cancer.…”

Section: Biological Factorsmentioning

confidence: 99%

Dental Erosion

Lussi¹,

Hellwig²,

Ganß³

et al. 2009

Operative Dentistry

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SUMMARYThere is some evidence that dental erosion is steadily spreading. To diagnose erosion, dental professionals have to rely on clinical appearance, as there is no device available to detect it. Adequate preventive measures can only be initiated if the different risk factors and potential interactions between them are known. When substance loss, caused by erosive tooth wear, reaches a certain degree, oral rehabilitation becomes necessary. Prior to the most recent decade, the severely eroded dentition could only be rehabilitated by the provision of extensive crown and bridgework or removable dentures. As a result of the improvements in composite restorative materials and in adhesive techniques, it has become possible to rehabilitate eroded dentitions in a less invasive manner.

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Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults

Cited by 118 publications

References 19 publications

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

The pH change after HCl titration into resting and stimulated saliva for a buffering capacity test

Dental Erosion

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