Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy

Cui, Ying; Zhu, Ying; Wang, Jay C.; Lu, Yifan; Zeng, Rebecca; Katz, Raviv; Vingopoulos, Filippos; Le, Rongrong; Laíns, Inês; Wu, David M.; Eliott, Dean; Vavvas, Demetrios G.; Husain, Deeba; Miller, Joan W.; Kim, Leo A.; Miller, John B.

doi:10.1136/bjophthalmol-2020-316245

Cited by 82 publications

(71 citation statements)

References 25 publications

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“…NVCs not identified on FA and identified on WF-OCTA (25%) consisted of combined small NVCs with little leakage only detectable on WF-OCTA and ILM segmentation errors generating false positives [86]. As already mentioned, Cui et al [80] reported similar results with comparable detection rates of NVC obtained with WF-OCTA and UWF-FA.…”

Section: Additional Observationssupporting

confidence: 57%

“…Furthermore, this group showed that WF-OCTA detected neovascularization in 88.6% of cases compared to the 72.2% of clinical examination, proving the value of WF-OCTA as an important complementary tool to clinical examination [67,79]. The work of Cui and collaborators [80] reinforced again the significantly superior detection rates of NVE with isolated WF-OCTA when compared to ultra-widefield CFP (UWF-CFP), and found similar detection rates when comparing WF-OCTA to ultra-widefield FA (UWF-FA).…”

Section: Nvementioning

confidence: 90%

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Update on Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging in Proliferative Diabetic Retinopathy

2021

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Proliferative diabetic retinopathy (PDR) is a major cause of blindness in diabetic individuals. Optical coherence tomography (OCT) and OCT-angiography (OCTA) are noninvasive imaging techniques useful for the diagnosis and assessment of PDR. We aim to review several recent developments using OCT and discuss their present and potential future applications in the clinical setting. An electronic database search was performed so as to include all studies assessing OCT and/or OCTA findings in PDR patients published from 1 January 2020 to 31 May 2021. Thirty studies were included, and the most recently published data essentially focused on the higher detection rate of neovascularization obtained with widefield-OCT and/or OCTA (WF-OCT/OCTA) and on the increasing quality of retinal imaging with quality levels non-inferior to widefield-fluorescein angiography (WF-FA). There were also significant developments in the study of retinal nonperfusion areas (NPAs) using these techniques and research on the impact of PDR treatment on NPAs and on vascular density. It is becoming increasingly clear that it is critical to use adequate imaging protocols focused on optimized segmentation and maximized imaged retinal area, with ongoing technological development through artificial intelligence and deep learning. These latest findings emphasize the growing applicability and role of noninvasive imaging in managing PDR with the added benefit of avoiding the repetition of invasive conventional FA.

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Section: Additional Observationssupporting

confidence: 57%

Section: Nvementioning

confidence: 90%

Update on Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging in Proliferative Diabetic Retinopathy

2021

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“…The increased area represents approximately 80 degrees of the total retina, which is still significantly less than the 200 degrees visualized by UWF-CI and UWF-FA imaging. However, despite the smaller area, WF-OCTA can detect over 95% of all neovascularization (NV) detected on UWF-FA [ 57 , 58 , 59 , 60 , 61 ]. WF-OCTA also has the added advantage of using the vitreoretinal interface (VRI) angio slab to improve detection rates of neovascularization [ 62 ].…”

Section: Wide Field Optical Coherence Tomography Angiography (Wf-octa) Quantitative Metricsmentioning

confidence: 99%

Ultrawide Field Imaging in Diabetic Retinopathy: Exploring the Role of Quantitative Metrics

Ashraf

Cavallerano

Sun

et al. 2021

JCM

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Ultrawide field imaging (UWF) has allowed the visualization of a significantly greater area of the retina than previous standard approaches. In diabetic retinopathy (DR), significantly more lesions are seen on UWF imaging compared to the seven-standard ETDRS fields. In addition, some eyes have lesions that are located predominantly in the peripheral retina that are associated with an increased risk of DR progression. The current DR severity scales are still largely based on clinically visible retinal microvascular lesions and do not incorporate retinal periphery, neuroretinal, or pathophysiologic changes. Thus, current scales are not well suited for documenting progression or regression in eyes with very early or advanced DR, nor in the setting of vascular endothelial growth factor inhibitors (antiVEGF). In addition, the categorical system is highly subjective, and grading is variable between different graders based on experience level and training background. Recently, there have been efforts to quantify DR lesions on UWF imaging in an attempt to generate objective metrics for classification, disease prognostication and prediction of treatment response. The purpose of this review is to examine current quantitative metrics derived from UWF fluorescein angiograms and UWF color imaging to determine their feasibility in any potential future DR classification.

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“…Ці інтраретинальні ділянки, які представлені звивистими, малодиференційованими дрібними повнокровними капілярами і венулами, об'єднують в одну клінічну ознаку -ІРМА [28]. Їх вираженість порівняно зі стандартною фотографією хоча б однієї зони також є одним з критеріїв при оцінці ступеня тяжкості ДР [29]. Висновки 1.…”

Section: клінічна офтальмологія / Clinical Ophthalmologyunclassified

Прогрессирование Начальной Диабетической Ретинопатии: Связь С состоянием Углеводного Обмена

Rykov¹,

Korobov²,

Mogilevskyy³

2021

AOU

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Background. Recognizing the early stages of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) and predicting their progression is important and is an urgent challenge of modern ophthalmology. The study aimed at investigating the peculiarities of occurrence and progression of DR initial studies and establishing its relationship with the severity of carbohydrate metabolism disorders in patients with T2DM. Materials and methods. We examined 91 patients (182 eyes) with T2DM. Based on the ETDRS system of clinical signs Airlie House, there were determined the microaneurysms (MA), microhemorrhages (MH), intraretinal microvascular anomalies (IRMA), retinal venous anomalies, retina nonperfusion, and their relationship with the severity of carbohydrate dysmetabolism in T2DM patients. Results. Most patients (72.5 %) had no retinopathy at the start of the study (ETDRS level was 0–10 in both eyes). The rest (27.5 %) had the ETDRS level 10 in one eye, while the other showed single changes in the caliber of blood vessels, dilatation, and tortuosity of the veins, IRMA or MH, which corresponded to the ETDRS level 14/15. In these patients, the duration of T2DM was longer (on average by 3 years), and the carbohydrate disorders were more pronounced. During one year of observation, eye changes progressed in different ways: in the absence of DR at the beginning of the study, progression was noted in 50.0 % of cases, while in their presence — in 92.0 %. The patients with progression had a longer history of diabetes and worse indicators of carbohydrate metabolism. Conclusions. It has been established that diabetic changes in the retina begin from a single vascular injury. With its presence within one year, DR develops in most cases.

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Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy

Cited by 82 publications

References 25 publications

Update on Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging in Proliferative Diabetic Retinopathy

Update on Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging in Proliferative Diabetic Retinopathy

Ultrawide Field Imaging in Diabetic Retinopathy: Exploring the Role of Quantitative Metrics

Прогрессирование Начальной Диабетической Ретинопатии: Связь С состоянием Углеводного Обмена

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