Comparison of Zeiss Cirrus and Optovue RTVue OCT Angiography Systems: A Quantitative and Qualitative Approach Examining the Three Capillary Networks in Diabetic Retinopathy

Chung, Christopher S.; Nesper, Peter L.; Park, Justin J.; Fawzi, Amani A.

doi:10.3928/23258160-20181101-18

Cited by 21 publications

(17 citation statements)

References 30 publications

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“…The results of this study indicate that while FAZ area could be reliably measured across all three devices, statistically significant differences were found in the VD metric for both the SCP and DCP layers, especially for the Angioplex device. Our findings regarding FAZ area is consistent with Chung et al who found no significant difference in FAZ area measurements between Angiovue and Angioplex 20. Other comparison studies involving devices not included in this study did not demonstrate consistency in FAZ area measurements across devices.…”

Section: Discussionsupporting

confidence: 90%

“…While Al-Sheikh et al revealed good repeatability for FAZ area between machines, Mihailovic et al and Corvi et al found significantly different FAZ areas across devices 11,18,19. In their study evaluating twenty eyes with diabetic retinopathy, Chung et al suggested that there was no significant difference in the VD between Angioplex and Angiovue 20. However, a study conducted by Munk et al, which imaged nineteen healthy subjects on four OCT-A machines (Angiovue, Triton, Angioplex, and Spectralis), revealed that Angioplex offers the best preservation of vessel continuity in both SCP and DCP 3.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

<p>Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease</p>

Lu¹,

Wang²,

Zeng³

et al. 2019

OPTH

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PurposeOptical coherence tomography angiography (OCT-A) has emerged as a novel tool for the non-invasive imaging and evaluation of the retinal microvasculature. There is little existing literature that compares OCT-A microvasculature metrics across different OCT-A devices in chorioretinal diseases. Herein, we examined these metrics on three available OCT-A platforms.Patients and methodsAll subjects were scanned on each of three OCT-A devices: Optovue Avanti Angiovue, Topcon DRI-OCT Triton Swept-Source OCT, and Zeiss Cirrus 5000-HD-OCT Angioplex. Two investigators independently measured foveal avascular zone (FAZ) area. Superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel densities (VD) were calculated from binarized images with ImageJ software. Image quality across devices was qualitatively compared. Interclass correlation coefficient (ICC), Bland-Altman analysis, repeated measures ANOVA, and post-hoc tests were performed for statistical analysis.ResultsThirteen eyes of seven patients with chorioretinal diagnoses were reviewed. ICC for FAZ measurement was 0.95. There was no significant difference in FAZ area across the three devices (p= 0.792). There was a significant difference in the SCP VD between the OCT-A devices (Triton 0.344 ± 0.013, Angiovue 0.323 ± 0.013, Angioplex 0.367 ± 0.014, p < 0.05). Significantly greater DCP VD was observed with Angioplex (0.385 ± 0.010) in comparison to both Triton (0.331 ± 0.009) and Angiovue (0.341 ± 0.020). A comparison of image quality revealed that Angiovue gives the highest quality, followed by Angioplex and Triton.ConclusionCore macular microvasculature metrics are now readily accessible on a variety of available OCT-A devices. While the FAZ can be reliably measured across all three devices in this study, there were significant differences for the vessel density in both the SCP and DCP. As a result, clinicians should be careful when comparing microvasculature metrics across different devices when using patient data in multicenter research investigations and clinical trials.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

<p>Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease</p>

Lu¹,

Wang²,

Zeng³

et al. 2019

OPTH

View full text Add to dashboard Cite

show abstract

“… 15 – 17 Furthermore, few studies have evaluated the ICP as a distinct plexus from either the SCP or DCP. 5 , 8 , 31 …”

Section: Discussionmentioning

confidence: 99%

Vascular Density of Deep, Intermediate and Superficial Vascular Plexuses Are Differentially Affected by Diabetic Retinopathy Severity

Ashraf

Sampani

Clermont

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to evaluate differences in optical coherence tomography angiography (OCTA) metrics in the superficial (SCP), intermediate (ICP), and deep (DCP) vascular plexuses across diabetic retinopathy (DR) severity levels. Methods This was a cross sectional observational retrospective chart review study. Eligible patients with diabetes who underwent same day RTVue XR Avanti OCTA, spectral-domain optical coherence tomography (SD-OCT), and 200-degree Optos ultrawide field color imaging. SCP, ICP, and DCP vessel density (VD) and vessel length density (VLD) were assessed using 3-D projection artifact removal software (PAROCTA) software. Results Of 396 eyes (237 patients), 16.1% had no DR, 26.9% mild nonproliferative DR (NPDR), 21.1% moderate NPDR, 12.1% severe NPDR, 10.1% proliferative DR (PDR) without panretinal photocoagulation (PRP), and 13.4% PDR with PRP. When comparing mild NPDR to no DR eyes, ICP and DCP VD and VLD were significantly lower, but there was no difference for SCP metrics. In eyes with more severe DR, there were significant differences in SCP VD and VLD between DR severity levels (mild versus moderate NPDR: VD 35.45 ± 3.31 vs. 34.14 ± 3.38, P = 0.008 and VLD 17.59 ± 1.83 vs. 16.80 ± 1.83, P = 0.003; moderate versus severe NPDR: VLD 16.80 ± 1.83 vs. 15.79 ± 1.84, P = 0.019), but no significant differences in ICP or DCP. Conclusions Although VD of each of the three individual layers decreases with increasing DR severity, DR severity has a substantially different effect on OCTA parameters within each layer. Vascular changes in eyes with no to early DR were present primarily in the deeper vascular layers, whereas in eyes with advanced DR the opposite was observed. This study highlights the effects of ICP and the importance of assessing SCP and DCP changes independently across each DR severity level.

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“…The algorithms used to calculate vessel density in OCT-A images vary; they may accompany instruments as proprietary software, or they may be made by research groups or companies to allow for post-image processing of exported images. As a result, the ensuing vessel density measurement of the same image sets or patients differ among the various devices, algorithms, scan locations, and scanned area sizes [ 42 – 45 ]. Moreover, studies comparing a variety of OCT-A-based algorithms to detect vessel density have found no single algorithm that outperforms others in all retinal plexuses examined [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Automated vessel density detection in fluorescein angiography images correlates with vision in proliferative diabetic retinopathy

et al. 2020

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To investigate the correlation between quantifiable vessel density, computed in an automated fashion, from ultra-widefield fluorescein angiography (UWFFA) images from patients with proliferative diabetic retinopathy (PDR) with visual acuity and macular thickness. Methods We performed a secondary analysis of a prospective randomized controlled trial. We designed and trained an algorithm to automate retinal vessel detection from input UWFFA images. We then used our algorithm to study the correlation between baseline vessel density and best corrected visual acuity (BCVA) and CRT for patients in the RECOVERY study. Reliability of the algorithm was tested using the intraclass correlation (ICC). 42 patients from the Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy (RECOVERY) trial who had both baseline UWFFA images and optical coherence tomography (OCT) data were included in our study. These patients had PDR without significant center-involving diabetic macular edema (central retinal thickness [CRT] �320μm). Results Our algorithm analyzed UWFFA images with a reliability measure (ICC) of 0.98. A positive correlation (r = 0.4071, p = 0.0075) was found between vessel density and BCVA. No correlation was found between vessel density and CRT.

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Comparison of Zeiss Cirrus and Optovue RTVue OCT Angiography Systems: A Quantitative and Qualitative Approach Examining the Three Capillary Networks in Diabetic Retinopathy

Cited by 21 publications

References 30 publications

<p>Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease</p>

<p>Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease</p>

Vascular Density of Deep, Intermediate and Superficial Vascular Plexuses Are Differentially Affected by Diabetic Retinopathy Severity

Automated vessel density detection in fluorescein angiography images correlates with vision in proliferative diabetic retinopathy

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