Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group

Dastgheib, Ladan; Mostafavi‐Pour, Zohreh; Abdorazagh, Ahmad Adnan; Khoshdel, Zahra; Sadati, Maryam Sadat; Ahrari, Iman; Ahrari, Sajjad; Ghavipisheh, Mahsa

doi:10.1155/2014/784863

Cited by 30 publications

(27 citation statements)

References 10 publications

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“…In one study [56] of 27 AA patients from Iran, serum and hair copper levels were lower in AA patients compared to controls. However, all other studies [54, 55, 57, 58] of serum copper levels identified no differences between AA patients and controls. Two of these studies [55, 58] also found no differences in magnesium levels.…”

Section: Micronutrientsmentioning

confidence: 85%

“…Two other small case-control studies [55, 56] found lower serum zinc levels in AA patients compared to controls. In contrast to these studies, two [57, 58] case-control studies from Finland (27 AA cases) and Iran (16 AA cases) found no difference in serum zinc levels of AA patients versus controls. The study from Finland revealed minimal differences in serum, red-cell, or 24-hour urine zinc concentrations compared to the general Finish population [58].…”

Section: Micronutrientsmentioning

confidence: 92%

“…The study from Finland revealed minimal differences in serum, red-cell, or 24-hour urine zinc concentrations compared to the general Finish population [58]. The study from Iran [57] also found no differences in serum and hair zinc levels between AA cases and controls.…”

Section: Micronutrientsmentioning

confidence: 99%

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The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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Section: Micronutrientsmentioning

confidence: 85%

Section: Micronutrientsmentioning

confidence: 92%

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The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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“…However, the association between AA and Zn deficiency seems contradictory, given that AA is an autoimmune disease, whereas Zn deficiency generally results in an impaired immune response [74,75]. In support of this association, some past studies have found no decreased serum Zn levels in AA patients [76][77][78]. In contrast, in the 2000s, several studies found decreased serum Zn levels in AA patients [60,[79][80][81][82].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Zinc and skin biology

Ogawa

Kawamura

Shimada

2016

Archives of Biochemistry and Biophysics

109

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“…Zinc also cause modulation of the activity of type 1 and 25α reductase. [11,12] Study by Otberg et al (2007) reported that the prevalence increases with age. Where 53% of men who age 40-49 years showed hair loss symptoms is moderate until severe according to the Hamilton degree grade 3 or more.…”

Section: Discussionmentioning

confidence: 99%

Hair’s Zinc Level on Androgenic Alopecia

Roem¹

2016

AJCEM

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Androgenic alopecia is characterized by progressive loss of hair from the scalp. This research aimed to determine the hair and blood zinc levels in men with androgenic alopecia. The research was conducted in the Departement of Dermatovenereology of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Center for Health Laboratory, Makassar, using the observational research method. The samples comprised 21 males with androgenic alopecia and 11 control samples without androgenic alopecia. The hair and blood of the samples were analyzed using the atomic absorption spectrophotometer receipts. The results showed that there was significant difference (p <0.05) between the levels of androgenic alopecia hair zinc and control. On blood zinc levels found no significant differences between androgenic alopecia and control. Hair zinc levels had a significant relationship with the degree of Hamilton, where the lower the levels of zinc in the hair androgenic alopecia, the greater the degree of Hamilton. However, things are different, between blood zinc levels in hair zinc levels and degrees of Hamilton that there is no significant difference. In this study also found between age and degree of Hamilton, where the increasing age, the greater the degree of Hamilton.

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Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group

Cited by 30 publications

References 10 publications

The Role of Micronutrients in Alopecia Areata: A Review

The Role of Micronutrients in Alopecia Areata: A Review

Zinc and skin biology

Hair’s Zinc Level on Androgenic Alopecia

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