Comparison of ε-Aminocaproic Acid and Tranexamic Acid in Reducing Postoperative Transfusions in Total Hip Arthroplasty

Churchill, Jessica L.; Puca, Kathleen E.; Meyer, Elizabeth S.; Carleton, Matthew; Truchan, Susan; Anderson, Michael J.

doi:10.1016/j.arth.2016.05.011

Cited by 26 publications

(28 citation statements)

References 20 publications

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“…Three included studies reported postoperative hemoglobin level [ 6 , 8 , 9 ]. There was no significant heterogeneity ( χ 2 = 0.17, df = 2, I 2 = 0%, P = 0.92); as a result, a fixed model was applied.…”

Section: Resultsmentioning

confidence: 99%

“…Three included studies reported the outcome of the transfusion units per patient [ 7 , 9 , 10 ]. The random model was employed according to a significant heterogeneity ( χ 2 = 26.32, df = 2, I 2 = 92%, P < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

“…The incidence of DVT had been reported in six studies [ 6 , 7 , 9 – 12 ]. The low significant heterogeneity was found, a fixed model was applied ( χ 2 = 1.17, df = 5, I 2 = 0%, P = 0.95).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies reported the length of hospital stay [ 7 , 9 ]. There was significant heterogeneity shown between the pooled results; therefore, a random model was applied ( χ 2 = 25.91, df = 1, I 2 = 96%, P < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis

Bai

et al. 2018

J Orthop Surg Res

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BackgroundWe conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy of aminocaproic acid in cases of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA).MethodsPotentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966–2017 October 31), PubMed (1966–2017 October 31), EMBASE (1980–2017 October 31), and ScienceDirect (1985–2017 October 31). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5.1.ResultsThree RCTs and four non-RCTs met the inclusion criteria. There were significant differences in total blood loss (mean difference (MD) = − 495.80, 95% CI − 837.29 to − 154.32, P = 0.004), drainage volume (MD = − 249.43, 95% CI − 286.78 to − 212.08, P < 0.00001), postoperative hemoglobin level (MD = 0.90, 95% CI 0.78 to 1.02, P < 0.00001), hemoglobin reduction (MD = − 0.75, 95% CI − 0.93 to − 0.57, P < 0.00001), transfusion rates (risk difference (RD) = − 0.17, 95% CI − 0.25 to − 0.09, P < 0.0001), average transfusion units (MD = − 0.28, 95% CI − 0.48 to − 0.09, P = 0.004), and length of hospital stay (MD = − 0.33, 95% CI − 0.43 to − 0.24, P < 0.00001) between the two groups. No significant differences were found regarding deep vein thrombosis (DVT) (RD = − 0.00, 95% CI − 0.01 to 0.00, P = 0.36) between the two groups.ConclusionsThe present meta-analysis indicated that the application of aminocaproic acid in THA or TKA decreases the total blood loss, drainage volume, transfusion rate, transfusion units per patient, and length of hospital stay and does not increase the risk of DVT.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis

Bai

et al. 2018

J Orthop Surg Res

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“…Recent studies have confirmed the efficacy of both IV and topical EACA administration in the context of THA. EACA could have an advantage in terms of cost; however, TXA is not very expensive to use (11,12). The combination of administration routes and the comparison with TXA should be expanded.…”

mentioning

confidence: 99%

Tranexamic acid and total hip arthroplasty: optimizing the administration method

Ollivier

Driessche²,

Billuart

et al. 2016

Ann. Transl. Med.

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Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Albayati,

Alardhi,

Khalbas

et al. 2024

ChemistrySelect

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Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence the toxicity of cells, the loading of therapeutic agents, and the release of active ions during the hemostasis process. Therefore, understanding the fundamentals of tuning these characteristics is important to design these types of carriers. While several literature reviews have explored the role of MSNs in hemorrhage control, comprehensive studies focusing on their general characteristics and specific applications remain scarce. This review concentrates on the principles of synthesizing mesoporous silica, the general types of MSNs, techniques for loading drugs methods onto the site of injury, release kinetics models, biocompatibility, toxicity, and the unique properties of MSNs. Furthermore, the article examines the mechanism of action of MSNs as nanomaterial hemostatic agents.

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Comparison of ε-Aminocaproic Acid and Tranexamic Acid in Reducing Postoperative Transfusions in Total Hip Arthroplasty

Cited by 26 publications

References 20 publications

The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis

The efficacy of intravenous aminocaproic acid in primary total hip and knee arthroplasty: a meta-analysis

Tranexamic acid and total hip arthroplasty: optimizing the administration method

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

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