Industrial processes need to be adjusted fast in order to generate a variety of products. The response to these modifications, the pneumatic control must be rebuilt in accordance with the new requirements, i.e., the control mechanism must be rebuilt. These issues could be resolved by utilizing the Karnaugh mapping method. The objective of this work is to develop multiple-actuator pneumatic circuits and reduce start-up times by merging various operational sequences into a single process. The Karnaugh maps is a technique for reducing logical equations or transforming truth tables into logic circuits. The method allows for circuit control using a programmable controller (PLC). One of the key advantages of using the suggested technique is the ease with which electrical schematic command circuits may be obtained. Schema will be created by simply using the pneumatic cylinder motion equations that were acquired from the Karnaugh map. The suggested technique assures not only the intended sequential cycle but also the minimizing of control command variables. This study focuses use Karnaugh Maps to develop a pneumatic control system in difficult cases with three different control sequences for five cylinders. Simulation software for pneumatic/electro-pneumatic circuits is utilized to apply the technique (Automation Studio and Fluid Sim). By applying the suggested rules, the logic equations were extracted in a simpler form, and they are simple to use pneumatically and electro pneumatically. It is also easily converted to Ladder Diagram Language. This method allows us to fast work in production cycles.