Comparison Study for Identifying Promoter Allelic Polymorphism in Interleukin 10 and Tumor Necrosis Factor α Genes

Agarwal, Poonam; Oldenburg, Mary C.; Czarneski, Jennifer; Morse, Ruth M.; Hameed, Meera; Cohen, Stanley A.; Fernandes, Helen

doi:10.1097/00019606-200009000-00006

Cited by 30 publications

(18 citation statements)

References 14 publications

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“…18,19 The presence of a G to A polymorphism at position 308 of the TNF a promoter gene could increase transcription six-to seven-fold. 20 It is obvious that the variable polymorphisms that lie within the promoter region of the TNF a locus make it a likely candidate for playing a regulatory role in disease. In our study, owing to the frequency of the À308A allele noted in POAG patients, we have to consider the possibility that a functional distinction between A…”

Section: Discussionmentioning

confidence: 99%

Association of tumour necrosis factor alpha −308 gene polymorphism with primary open-angle glaucoma in Chinese

Lin

Tsai

Chen

et al. 2003

Eye

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Purpose Genetic factors are known to play a role in the aetiology of glaucoma, and in particular the role of the immune system is highly suspected. In this study, we evaluated the association between tumour necrosis factor alpha À308 (TNF a À308) and primary open-angle glaucoma (POAG). Methods A total of sixty POAG patients and 103 healthy volunteers as control group were enrolled in this case-controlled study. Furthermore, we used polymerase chain reaction based analysis to resolve the TNF a À308 polymorphism. Statistical analysis for the relative risk of TNF a À308 polymorphism was compared by the v 2 test.Results There were significant differences in the distribution of the polymorphism between the POAG patients and the control subjects (P ¼ 0.00016; Po0.05) and it was found that the A À308 allele occurred more frequently in POAG patients (odds ratio: 2.72; 95% confidence interval: 1.66-4.45).Conclusion The results of our study concluded that the distribution of TNF a À308 was significantly higher in the POAG patients than in the control group. Therefore, the A À308 allele appears to be associated with POAG and, therefore, could be used as a genetic marker for disease mapping. POAG is a complex disease, and a single gene could not be responsible. Understanding the role of genetic polymorphisms, like TNF a, could be a prediction of the disease and useful for developing new treatments for POAG.

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Section: Discussionmentioning

confidence: 99%

Association of tumour necrosis factor alpha −308 gene polymorphism with primary open-angle glaucoma in Chinese

Lin

Tsai

Chen

et al. 2003

Eye

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“…Agarwal et al (50) found that a G-to-A polymorphism at position Ϫ308 in the promoter region of the TNF-␣ gene increases transcription up to sevenfold and that the G-to-A polymorphism at position Ϫ1082 of the IL-10 promoter results in lower levels of IL-10 protein.…”

Section: Discussionmentioning

confidence: 99%

Mycophenolate mofetil-based immunosuppression and cytokine genotypes: effects on monokine secretion and antigen presentation in long-term renal transplant recipients

Weimer¹,

Mytilineos

Feustel

et al. 2003

Transplantation

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“…24 The presence of a G to A polymorphism at position 308 of the TNF-a promoter gene could increase transcription six-to seven-fold. 25 The IL-1b gene is located on chromosome 2, in close linkage with another gene of the IL-1 gene family that encodes for IL-1Ra. Different polymorphisms have been described in the IL-1b gene and at least two of them could influence the protein production: one located in the promoter region at position À511, 19 and the other in exon 5.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of TNF-α and IL-1β polymorphisms in Taiwan Chinese patients with pterygium

Tsai

Lee

Tseng

et al. 2004

Eye

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Purpose Pterygium, a complex disease, is associated with ultraviolet radiation, immunoinflammatory process, genetic factors, and virus infection. Ultraviolet radiation induces secretion of proinflammatory cytokines by the ocular surface epithelium, inflammatory cells in the tear fluid, or both. Among these cytokines, tumour necrosis factor (TNF)a and interleukin (IL)-1b activate pterygium body fibroblasts, resulting in a phenotype capable of expressing various proteinases associated with extracellular matrix remodelling, angiogenesis, and fibroblast proliferation, which are important for pterygium formation and recurrence. The genetic factor was proposed to play a role in pterygium formation, but there were few studies to clarify this proposition. For investigating genetic factors, the association between pterygium and TNF-a and IL-1b polymorphisms is evaluated in this study. Methods A total of 128 pterygium patients and 103 volunteers without pterygium were enrolled in this study. Polymerase chain reaction-based analysis was used to resolve the TNF-a-308 promoter, IL-1b-511 promoter, IL-1b exon 5, and IL-1 receptor antagonist (IL-1 Ra) polymorphisms. Results There were no significant differences in the frequency of genotypes and alleles of TNF-a-308 promoter, IL-1b-511 promoter, IL-1b exon 5, and IL-1 Ra polymorphisms between both groups. Conclusions The correlation between pterygium and TNF-a-308 promoter, IL-1b-511 promoter, IL-1b exon 5, and IL-1 Ra polymorphisms does not exist and those polymorphisms are not useful genetic markers for pterygium susceptibility. Further studies on other polymorphisms or haplotypes of TNF-a and IL-1b are necessary.

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Comparison Study for Identifying Promoter Allelic Polymorphism in Interleukin 10 and Tumor Necrosis Factor α Genes

Cited by 30 publications

References 14 publications

Association of tumour necrosis factor alpha −308 gene polymorphism with primary open-angle glaucoma in Chinese

Association of tumour necrosis factor alpha −308 gene polymorphism with primary open-angle glaucoma in Chinese

Mycophenolate mofetil-based immunosuppression and cytokine genotypes: effects on monokine secretion and antigen presentation in long-term renal transplant recipients

Evaluation of TNF-α and IL-1β polymorphisms in Taiwan Chinese patients with pterygium

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