Comparison study of clinicopathological features of cellular schwannoma between retroperitoneum and other sites

Zhang, Xiaoying; Liu, Liping; Zhong, Yan; Wang, Lihua; Ren, Yanzhi

doi:10.21037/atm-22-4979

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…The increased content of GFAP following PNI promotes axonal growth along topographical cues provided by fibrous scar tissues. MBP, primarily distributed in myelin sheaths and nuclei, serves as an indicator for assessing myelin sheath regeneration during PNR [ 88 ]. In addition to GFAP and MBP, we also conducted immunofluorescence staining for NF200 and Tuj-1.…”

Section: Resultsmentioning

confidence: 99%

Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration

Liu,

Yan,

Liu

et al. 2024

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration

Liu,

Yan,

Liu

et al. 2024

Materials Today Bio

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Long-term postoperative outcomes of spinal cellular schwannoma: study of 93 consecutive cases

Jia,

Lou,

Chen

et al. 2024

The Spine Journal

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Clinicopathological differences between classical schwannomas and cellular schwannomas in the retroperitoneum

Zhang,

Zheng,

et al. 2024

Journal of Neuropathology &Amp; Experimental Neurology

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This study aimed to compare clinical and pathological features of retroperitoneal classical schwannomas and cellular schwannomas. A total of 64 cases of retroperitoneal classical schwannoma and 48 cases of cellular schwannoma were studied. Histopathological analysis was performed using hematoxylin and eosin staining and immunohistochemistry. Retroperitoneal cellular schwannomas exhibited 100% (48/48) and 75% (36/48) positive expression for glial fibrillary acidic protein (GFAP) and cytokeratins (CK), respectively. Classical schwannomas showed rates of 6.25% (4/64) and 15.63% (10/64), respectively (P < .05). In classic schwannomas, 85.9% (55/64) showed a reticular pattern of positive anti-CD34 staining around tumor margins and subcapsular areas vs 52.1% (25/48) in cellular schwannomas (P < .05). Cellular schwannomas exhibited more mitotic figures than classical schwannoma (P < .05). The recurrence rate of cellular schwannomas was 10.42% (5/48), while that of classical schwannomas was 1.56% (1/64) (P < .05). Retroperitoneal cellular schwannomas commonly express GFAP and CK compared to classical schwannomas, suggesting that cellular schwannoma may originate from unmyelinated Schwann cells, while classical schwannoma may originate from myelinated Schwann cells. Anti-CD34 staining patterns may be used to distinguish between the 2 types. Retroperitoneal cellular schwannomas also show higher mitotic activity and are more prone to recurrence.

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Comparison study of clinicopathological features of cellular schwannoma between retroperitoneum and other sites

Cited by 3 publications

References 24 publications

Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration

Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration

Long-term postoperative outcomes of spinal cellular schwannoma: study of 93 consecutive cases

Clinicopathological differences between classical schwannomas and cellular schwannomas in the retroperitoneum

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