Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial

Oshvandi, Khodayar; Safari, Mehri; Gholyaf, Mahmoud; Moghimbeygi, Abbas; Shamsaei, Farshid; Tamadon, Mohammad-Reza; Alimohammadi, Neda

doi:10.15171/jrip.2019.19

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…12 Oshvandi et alalso demonstrated that high flux dialyzers improved the quality of life of patients as compared to low flux dialyzers. 13 Our study associated high-flux membranes with greater protein loss than low-flux membranes. Our results are in contrast to observations made previously.…”

Section: Discussionmentioning

confidence: 65%

Effect of Different Dialysis Membranes on Protein Loss During Hemodialysis

Mir

Raja

Azam

et al. 2023

PAFMJ

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Objective: To compare the loss of proteins with high and low flux hemodialysis membranes. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Nephrology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Nov 2019 to Feb 2020. Methodology: This study was conducted on patients with end-stage renal disease on maintenance haemodialysis. We excluded patients on haemodialysis for less than one month, those with poor compliance to hemodialysis, those undergoing hemodialysis for less than four hours per session and unwilling patients. Patients were divided into two groups: one was dialyzed with high flux membranes, whereas low flux membranes were used for the other group. Dialysate samples were collected during the first hour and then during the last hour of each haemodialysis session to estimate protein losses in each group. Results: Data were recorded during 133 hemodialysis sessions, the patients underwent. There were 22 patients, including 12 (54.55%) males, having a mean age of 46.45±13.99 years. Most patients (17, 77.27%) were on twice-a-week dialysis, whereas the rest were dialyzed thrice weekly. Protein loss was 0.45± 0.23g/L with low flux membranes and 1.20±0.60g/L with high flux membranes. This difference was statistically significant (p= <0.001). Conclusion: High flux dialysis membranes are associated with greater protein loss during hemodialysis.

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Section: Discussionmentioning

confidence: 65%

Effect of Different Dialysis Membranes on Protein Loss During Hemodialysis

Mir

Raja

Azam

et al. 2023

PAFMJ

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Protein adsorption phenomena in hemodialysis membranes: Mechanisms, influences of clinical practices, modeling, and challenges

Westphalen

Abdelrasoul

Shoker

2021

Colloid and Interface Science Communications

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Measuring quality of life in trials including patients on haemodialysis: methodological issues surrounding the use of the Kidney Disease Quality of Life Questionnaire

Worboys

Cooper

Burton

et al. 2022

Nephrology Dialysis Transplantation

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Background Haemodialysis (HD) treatment causes a significant decrease in quality of life (QoL). When enrolled in a clinical trial, some patients are lost prior to follow-up because they die or they receive a kidney transplant. It is unclear how these patients are dealt with in the analysis of QoL data. There are questions surrounding the consistency of how QoL measures are used, reported and analysed. Methods A systematic search of electronic databases for trials measuring QoL in HD patients using any variation of the Kidney Disease Quality of Life (KDQoL) Questionnaire was conducted. The review was conducted in Covidence version 2. Quantitative analysis was conducted in Stata version 16. Results We included 61 trials in the review, of which 82% reported dropouts. The methods to account for missing data due to dropouts include imputation (7%) and complete case analysis (72%). Few trials (7%) conducted a sensitivity analysis to assess the impact of missing data on the study results. Single imputation techniques were used, but are only valid under strong assumptions regarding the type and pattern of missingness. There was inconsistency in the reporting of the KDQoL, with many articles (70%) amending the validated questionnaires or reporting only statistically significant results. Conclusions Missing data are not dealt with according to the missing data mechanism, which may lead to biased results. Inconsistency in the use of patient-reported outcome measures raises questions about the validity of these trials. Methodological issues in nephrology trials could be a contributing factor to why there are limited effective interventions to improve QoL in this patient group. PROSPERO Registration CRD42020223869

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Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial

Cited by 4 publications

References 27 publications

Effect of Different Dialysis Membranes on Protein Loss During Hemodialysis

Effect of Different Dialysis Membranes on Protein Loss During Hemodialysis

Protein adsorption phenomena in hemodialysis membranes: Mechanisms, influences of clinical practices, modeling, and challenges

Measuring quality of life in trials including patients on haemodialysis: methodological issues surrounding the use of the Kidney Disease Quality of Life Questionnaire

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