Comparisons Between Bacterial Communities in Mucosa in Patients With Gastric Antrum Ulcer and a Duodenal Ulcer

Chen, Xia; Xia, Chenmei; Li, Qianqian; Jin, Linxiao; Zheng, Liyun; Wu, Zhongbiao

doi:10.3389/fcimb.2018.00126

Cited by 24 publications

(20 citation statements)

References 13 publications

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“…Another study compared mucosal microbiota composition in duodenal and gastric ulcers and showed that the same genera are present in both locations, and again showed different abundance of genera including Prevotella , Neisseria and Streptococcus which were significantly lower in gastric samples when compared to duodenal samples. However, this might be a consequence of ecosystem changes due to the presence of Helicobacter . Many predominant gastric and oral bacteria such as Lactobacillus , Streptococcus or Veillonella species are very active in the small intestine .…”

Section: Resultsmentioning

confidence: 99%

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Systematic review: gastric microbiota in health and disease

Rajilić‐Stojanović¹,

Figueiredo²,

Smet³

et al. 2020

Aliment Pharmacol Ther

127

112

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Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next‐generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty‐five papers were eligible for inclusion. With the exception of H pylori‐induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.

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Section: Resultsmentioning

confidence: 99%

“…However, this might be a consequence of ecosystem changes due to the presence of Helicobacter 54. Many predominant gastric and oral bacteria such as Lactobacillus, Streptococcus or Veillonella species are very active in the small intestine 55.…”

mentioning

confidence: 99%

Systematic review: gastric microbiota in health and disease

Rajilić‐Stojanović¹,

Figueiredo²,

Smet³

et al. 2020

Aliment Pharmacol Ther

127

112

View full text Add to dashboard Cite

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“…The relative abundance of the phylum Bacteroidetes in the LBP and MIX groups tended to be slightly increased, but was not significantly different among five groups. The phyla Proteobacteria , Bacteroidetes , and Firmicutes were predominant in patients with Helicobacter pylori -positive gastric antrum ulcer or duodenal ulcer [ 69 ]. The phylum Proteobacteria was mostly abundant in gastric antrum of the patients with Helicobacter pylori -positive gastric antrum ulcer, and the phyla Bacteroidetes and Firmicutes were mostly abundant in the duodenum of patients with Helicobacter pylori -positive duodenal ulcers [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Combined Lycium barbarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats

et al. 2021

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Background Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats. Methods Male Sprague–Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks. Results The MIX group elevated gastric cyclooxygenase-1, prostaglandin E2, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (p < 0.05). Moreover, the MIX group reduced lipid peroxides malondialdehyde levels by 78% (p < 0.05). The treatment of LBP and/or CPC increased gastric Bifidobacterium relative abundance by 2.5–4.0 times compared with the aspirin group (p < 0.05). Conclusions We conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.

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“…3,4 Prevotella, Neisseria, Staphylococcus, and Streptococcus have been reportedly found in the stomach; however, some of these bacteria were found also in the esophagus with less-studied clinical relevance. [5][6][7] Evidence suggests that colonization by some species, for example, Streptococcus salivarius, which have urease activity, generates a less acidic environment, thus favoring H. pylori colonization. 8 Hansson et al have described that the production of acid in the antrum is increased mainly after gastritis whereas the risk of gastric cancer is slightly reduced.…”

Section: Introductionmentioning

confidence: 99%

Colonization by Pseudomonas aeruginosa and Staphylococcus aureus of Antral Biopsy Specimens from Gastritis Patients Uninfected with Helicobacter Pylori

Kachuei

Abadi

Rahimi

et al. 2020

IDR

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Purpose: Roles and incidence of some microorganisms that transiently or permanently colonize the human stomach are still unknown despite advances in gastroenterology. We aimed to examine the incidence of four microorganisms, Helicobacter pylori, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis, in the antral biopsy specimens of patients with gastroduodenal conditions. Patients and Methods: Patients (67 females, 33 males; mean age = 49.5 years) were initially examined and diagnosed by a gastroenterologist at the Mehrad Hospital, Tehran, Iran. We enrolled those who underwent the upper gastrointestinal endoscopy because of gastroduodenal conditions. Two antral biopsy samples were taken by endoscopy; the first sample was used for the "rapid urease test" to confirm H. pylori. The second was used for DNA extraction and PCR analyses with specific, corresponding primer sets to establish the presence of the four microorganisms. Our study was approved by the Ethics Committee at the Tarbiat Modares University, Tehran. Results: Based on pathology and endoscopy findings, we divided the patients into three groups: 62 presented with gastritis, 18 with duodenal ulcer, and 20 gastric ulcer. The number of patients with P. aeruginosa but without H. pylori significantly differed from the number of those co-infected with both microorganisms (P = 0.03). Additionally, a similar significance was found between the incidence of S. aureus in patients without H. pylori and those with both infections (P = 0.04). Our results indicated that a significant number of patients with gastritis were colonized with P. aeruginosa or S. aureus without being co-infected with H. pylori (P < 0.001). Interestingly, the incidence of colonization by P. aeruginosa of patients without H. pylori (45/49, 91.8%) was higher than that by S. aureus (28/49, 57%). Conclusion:The number of patients without H. pylori but with P. aeruginosa or with S. aureus infection significantly differed from that with both infections, respectively. Our study thus shows that patients without H. pylori infection are prone to be colonized by P. aeruginosa or S. aureus, indicating that targeted antibiotic regimens are necessary for clinically treating them.

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Comparisons Between Bacterial Communities in Mucosa in Patients With Gastric Antrum Ulcer and a Duodenal Ulcer

Cited by 24 publications

References 13 publications

Systematic review: gastric microbiota in health and disease

Systematic review: gastric microbiota in health and disease

Combined Lycium barbarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats

<p>Colonization by <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> of Antral Biopsy Specimens from Gastritis Patients Uninfected with <em>Helicobacter Pylori</em></p>

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