Comparisons of glucose–insulin homeostasis following maprotiline and fluoxetine treatment in depressed males

Chen, Yi-Chyan; Shen, Yu-Chih; Hung, Yi‐Jen; Chou, Chao-Ha; Yeh, Chin‐Bin; Perng, Cheng-Hwang

doi:10.1016/j.jad.2007.01.023

Cited by 22 publications

(11 citation statements)

References 19 publications

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“…The observations from the 17 case reports are supported by evidence from randomized controlled trials that have reported both hyperglycemic and hypoglycemic effects of antidepressant agents. Furthermore, in individuals without diabetes, use of antidepressants has been observed to be associated with a significant increase in the risk of hyperglycemia and diabetes [5][6][7]. In contrast to the case reports and the studies by Derijks et al, the evidence from randomized controlled trials in patients with diabetes appear to suggest that the effect of antidepressants on glycemic control differs according to antidepressant class.…”

Section: Discussionmentioning

confidence: 92%

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Glucose dysregulation associated with antidepressant agents: an analysis of 17 published case reports

Khoza

Barner

2011

Int J Clin Pharm

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It is not clear from published case reports whether changes in glucose regulation, following antidepressant therapy initiation are due to antidepressants or changes in mood and lifestyle. Nonetheless, healthcare providers should be aware of the potential changes in glucose regulation especially in the first month of antidepressant therapy, and use appropriate clinical and laboratory monitoring to prevent serious adverse events in patients at risk.

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Section: Discussionmentioning

confidence: 92%

“…Furthermore, the evidence from randomized controlled trials (RCTs) has also been equivocal. While two RCTs observed an increase in the risk for diabetes associated with use of antidepressant agents [5,6], use of antidepressants in another RCT was observed to cause a decrease in fasting plasma glucose [7].…”

Section: Introductionmentioning

confidence: 96%

Glucose dysregulation associated with antidepressant agents: an analysis of 17 published case reports

Khoza

Barner

2011

Int J Clin Pharm

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“…This SSRI effect is an important distinction as some studies show that various antidepressants have different effects on metabolism. Although data are not entirely consistent, it appears that in general, serotonergic antidepressants have hypoglycemic effects [41], whereas noradrenergic antidepressants exert opposite effects [42, 43], and dual mechanism drugs may not alter glucose homeostasis [44]. In contrast, some studies have shown no no effect for depression treatment on Si [22].…”

Section: Discussionmentioning

confidence: 99%

Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes

Wagner

Allen

Swalley

et al. 2009

Diabetes Research and Clinical Practice

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Aims-To compare insulin sensitivity (Si) in adults at risk for type 2 diabetes (T2DM) who were categorized as non-depressed, treated for depression and untreated depression after controlling for PA (PA).Methods-Baseline data was analyzed from individuals enrolled in a diabetes prevention program (n=56). Si was calculated using the whole body insulin sensitivity method. The Centers for Epidemiologic Studies Depression Scale (CESD) was used to assess depressive symptoms and depressed cases were identified using a cutoff of ≥16. Depression treatment was identified using a self-report form validated by medical chart review. The PA subscale of the Health Promoting Lifestyle Profile was used to determine PA levels.Results-One third of participants had elevated depressive symptoms; 19% were taking antidepressant medication. Mean Si was 3.0 (±1.9). In ANOVA, depressed individuals (M=1.79 ±0.91) showed significantly lower Si than non-depressed individuals (M=3.39±1.78). However, individuals taking antidepressant medications had Si similar to non-depressed individuals (M=3.10 ±1.86: p=.63). In ANCOVA this association remained after controlling for PA.Conclusions-These data suggest that in adults at high risk for T2DM, depression treatment may improve insulin resistance observed in depression. Healthcare practitioners are encouraged to screen, treat, or refer their patients with depression for treatment.

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“…Symptomatic depressed patients have a higher incidence of hyperinsulinemia and hyperglycemia (Lewis et al . 1983, Winokur et al 1988, Chen et al . 2007, Hung et al .…”

Section: Introductionmentioning

confidence: 99%

“…There are multiple proposed pathophysiological mechanisms for the association between chronic psychological stress or depression and insulin resistance or diabetes (Lewis et al . 1983, Winokur et al 1988, Peyrot & Rubin, 1997, Katon et al 2004, Chen et al . 2007, Hung et al .…”

Section: Introductionmentioning

confidence: 99%

Acute psychological stress results in the rapid development of insulin resistance

Li¹,

Li²,

Zhou³

et al. 2013

Journal of Endocrinology

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In recent years, the roles of chronic stress and depression as an independent risk factor for decreased insulin sensitivity and the development of diabetes have been increasingly recognized. However, an understanding and the mechanisms linking insulin resistance and acute psychological stress are very limited. We hypothesized that acute psychological stress may cause the development of insulin resistance, which may be a risk factor in developing type 2 diabetes. We tested the hypothesis in a well-established mouse model using 180 episodes of inescapable foot shock (IES), followed by a behavioral escape test. In this study, mice that received IES treatment were tested for acute insulin resistance by measuring glucose metabolism and insulin signaling. When compared to normal and sham mice, mice that were exposed to IES resulting in escape failure (defined as IES with behavioral escape failure) displayed elevated blood glucose levels in both glucose tolerance and insulin tolerance tests. Furthermore, mice with IES exposure and behavioral escape failure exhibited impaired hepatic insulin signaling via the insulin-induced insulin receptor/insulin receptor substrate 1/Akt pathway, without affecting similar pathways in skeletal muscle, adipose tissue and brain. Additionally, a rise in murine growth-related oncogene KC/GRO was associated with impaired glucose metabolism in IES mice, suggesting a mechanism by which psychological stress by IES may influence glucose metabolism. The present results indicate that psychological stress induced by IES can acutely alter hepatic responsiveness to insulin and affect whole-body glucose metabolism.

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Comparisons of glucose–insulin homeostasis following maprotiline and fluoxetine treatment in depressed males

Cited by 22 publications

References 19 publications

Glucose dysregulation associated with antidepressant agents: an analysis of 17 published case reports

Glucose dysregulation associated with antidepressant agents: an analysis of 17 published case reports

Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes

Acute psychological stress results in the rapid development of insulin resistance

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