Comparisons of Oncological and Functional Outcomes Between Primary Whole-Gland Cryoablation and High-Intensity Focused Ultrasound for Localized Prostate Cancer

Abstract

In this study, both primary whole-gland cryoablation and HIFU demonstrated good oncological outcomes for localized prostate cancer. We validated the safety of the two treatment modalities and identified the importance of combined HIFU and transurethral resection of the prostate. The HIFU patients experienced better urinary function improvement and more possible sexual function preservation than the cryoablation patients; therefore, HIFU may provide better quality of life for patients with localized prostate cancer.

Comparisons of oncological and functional outcomes among radical retropubic prostatectomy, high dose rate brachytherapy, cryoablation and high-intensity focused ultrasound for localized prostate cancer

“…If preoperative prostate volume was <30 mL, TURP and HIFU would be performed simultaneously. If preoperative prostate volume was ≥30 mL, HIFU would be performed 4 weeks later after TURP (Liu and Chiang 2016). …”

Urologic cancer in Taiwan

“…In 2-year follow-up, Liu et al reported that both primary whole-gland cryoablation and HIFU demonstrated good oncological outcomes for localized prostate cancer. The HIFU patients experienced better urinary function improvement and more possible sexual function preservation than the cryoablation patients (17). They also identified the D'Amico high-risk group, postoperative PSA nadir >0.3 ng/ml and time to PSA nadir <3 months as predictors for biochemical recurrence after primary whole-gland prostate cryoablation (18).…”

A comparison of time taken to return to baseline erectile function following focal and whole gland ablative therapies for localized prostate cancer: A systematic review

“…Of 222 studies initially identified on 2 February 2017, 17 studies met the inclusion criteria after removal of duplicates, non-English language, reviews, letters, case reports, non-human studies and non-full text articles (figure 1) [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] . Three papers were excluded after full text examination as WG and focal cryotherapy were amalgamated.…”

“…Focal PT, VTP and IRE appeared to cause very little change from baseline though the men in these studies tended to have low volume lesions. The lack of randomized studies means intermodality comparison is difficult though from Li et al's and Liu et al's nonrandomized comparative studies, it would appear that WG HIFU is associated better EF than both focal and WG cryotherapy 28,30 . ED after HIFU is likely to result from heat dissemination to the surrounding cavernosal nerves and accessory or aberrant pudendal arteries found in up to 75% of men 28,39 .…”

“…Liu et al, Li et al and Barret et al compared different ablative treatments in the same study though none of the studies were randomized 24,28,30 .…”