Comparisons of steroid, acyclovir, lipoprostoglandin E1 and steroid+acyclovir treatments in facial paralysis: A rat study

Gök, Üzeyir; Alpay, Hayrettin Cengiz; Akpolat, Nusret; Yoldaş, Tahir Kurtuluş; Kılıç, Abdullah; Yılmaz, Bayram; Kabakuş, Nimet

doi:10.1016/j.ijporl.2005.03.025

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…These results are similar to the results from a previous study showing that there is no significant difference in the recovery period between treatments. 10 Figure 3 shows that the patients with DFP experienced significantly better clinical courses of recovery. Based on this result, it can be assumed that the occurrence of DFP is correlated with good outcomes in MVD.…”

Section: Discussionmentioning

confidence: 96%

Delayed facial palsy after microvascular decompression for hemifacial spasm: friend or foe?

Lee¹,

Park

Choi³

et al. 2018

Journal of Neurosurgery

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OBJECTIVE The authors investigated the incidence, clinical course, and predisposing factors associated with delayed facial palsy (DFP) following microvascular decompression (MVD). METHODS The authors reviewed the records of 310 patients (311 cases) who were followed after MVD for hemifacial spasm (HFS). Of these patients, 45 (14.5%) developed DFP after MVD. The clinical characteristics and predisposing factors of the patients with HFS were investigated to identify prognostic factors that predicted the development of DFP after MVD. Log-rank tests were used to compare times to symptom disappearance, and a logistic regression analysis was performed to compare clinical characteristics between patients who developed DFP and those who did not. RESULTS HFS was completely resolved immediately after MVD in 158 cases (50.8%), and HFS eventually disappeared in 289 (92.9%) of the cases. Of the 45 patients with DFP, 17 were men and 28 were women. DFP occurred between postoperative Days 1 and 44 (mean 9.67 days). Finally, 44 patients (97.8%) completely recovered. The average time to recovery was 3.9 months (range 1-24 months). Patients who had experienced an immediate disappearance of HFS experienced a significantly higher occurrence of DFP than those who did not (odds ratio 0.383, 95% confidence interval 0.183-0.802; p = 0.011). In addition, preoperative botulinum neurotoxin injections negatively influenced the occurrence of DFP (p = 0.016). CONCLUSIONS In this study, the incidence rate of DFP was slightly higher than previously reported values. Moreover, DFP can occur even when spasms disappear immediately after MVD, but the patients with DFP can fully recover within weeks.

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Section: Discussionmentioning

confidence: 96%

Delayed facial palsy after microvascular decompression for hemifacial spasm: friend or foe?

Lee¹,

Park

Choi³

et al. 2018

Journal of Neurosurgery

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“…Gök et al induced mild facial palsy in rats using the KOS strain of HSV-1. However, the strain of rats used was unclear, and they did not assess HSV-1 infection [13]. Kumagami et al induced complete facial palsy by injecting HSV-1 into the stylomastoid foramen of the facial nerve of rabbits [9].…”

Section: Discussionmentioning

confidence: 99%

Facial paralysis induced by ear inoculation of herpes simplex virus in rat

et al. 2017

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“…However, the role of antiviral drugs is controversial. [ 5 6 7 8 9 10 ] Corticosteroids, currently, remain the single most important treatment option. [ 11 12 ] Bell's palsy, usually, occur rapidly, and any pharmacological intervention is difficult.…”

Section: Introductionmentioning

confidence: 99%

Single dose intravenous methyl prednisolone versus oral prednisolone in Bell′s palsy: A randomized controlled trial

et al. 2015

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Objectives:Corticosteroids have been used in the treatment of Bell's palsy and several other postinfectious neurological conditions. We hypothesized that administration of a single dose of intravenous (IV) methylprednisolone might be an effective alternative to oral prednisolone.Materials and Methods:In this open label, randomized trial, patients with acute Bell's palsy were randomized into two groups. One group received single dose (500 mg) of IV methylprednisolone while the other group received 10 days of oral prednisone. Outcome was assessed at 1 and 3 months with House–Brackmann scale.Results:At 3 months, 93 (79.48%) patients had completely recovered. IV methylprednisolone and oral prednisolone groups had similar recovery rates (80% vs. 78.33%, P > 0.05). Patients with Grade 2 and 3 recovered completely. In patients with Grade 6, the recovery rate was 20%. A better outcome was observed if corticosteroids were administered within 3 days of onset of palsy.Conclusion:Intravenous methylprednisolone and oral prednisolone showed equivalent benefit in patients with acute Bell's palsy.

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Comparisons of steroid, acyclovir, lipoprostoglandin E1 and steroid+acyclovir treatments in facial paralysis: A rat study

Cited by 6 publications

References 34 publications

Delayed facial palsy after microvascular decompression for hemifacial spasm: friend or foe?

Delayed facial palsy after microvascular decompression for hemifacial spasm: friend or foe?

Facial paralysis induced by ear inoculation of herpes simplex virus in rat

Single dose intravenous methyl prednisolone versus oral prednisolone in Bell′s palsy: A randomized controlled trial

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