Compartment Syndrome Due to Massive Leg Hematoma After Primary Total Hip Arthroplasty

Hannon, Michael G.; Lamont, Justin G.

doi:10.1016/j.arth.2011.10.032

Cited by 10 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies described hematoma formation as a complication after THR; however, none of these studies described a method for the accurate clinical evaluation of the hematoma’s extent. 1 , 3 , 5 - 9 In our opinion, the method described in the current study is a reliable and easy method to measure the size of a hematoma, which can be particularly useful in research. Future studies should investigate if the proposed classification presents a correlation with complication rates or clinical parameters such as post-operative pain.…”

Section: Discussionmentioning

confidence: 83%

“…Possible etiologies include the following: postoperative trauma, anticoagulation drug complications, or irritation of the iliopsoas tendon. 7 - 9 In more severe cases, hematomas can lead to vascular and neurological injuries. 10 , 11 Readmissions for hematoma surgical treatment negatively impact referral hospitals, increasing health care costs and patient morbidity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two Classifications for Surgical Wound Hematoma After Total Hip Replacement

et al. 2018

View full text Add to dashboard Cite

Objective:To determine the reliability of two classification methods for wound hematoma after total hip replacement. Methods:This prospective cohort study was conducted on patients who underwent total hip replacement for hip osteoarthritis between May 2014 and April 2015. Epidemiological, surgical, and functional data were assessed. Two experienced hip surgeons evaluated 75 pictures of wounds taken 24 hours after surgery. Both evaluators performed the analysis twice, with a 6-week interval between the two analyses. The subjective classification was divided into four different categories describing the hematoma: absent, mild, moderate, and severe. The objective classification was derived from mathematical calculation of the area of the hematoma using a grid superimposed on a picture of the wound. Results:The subjective classification demonstrated an intra-rater agreement of more than 70%, while kappa values showed poor to moderate inter-rater reliability. The objective classification based on mathematical measurements of the hematoma area was more reliable, with good to excellent intra- and inter-rater reliability. Conclusion:The objective classification demonstrated higher intra- and inter-rater reliability. The classification methods used in this study could serve as a useful instrument for orthopedic surgeons, researchers, and health care providers when assessing wound hematomas after total hip replacement. Level of Evidence II; Development of diagnostic criteria on consecutive patients (with universally applied reference ‘‘gold’’ standard).

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Two Classifications for Surgical Wound Hematoma After Total Hip Replacement

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Fondaparinux is primarily metabolized through the kidney, and thus, is contraindicated in renal-impaired patients (creatinine clearance < 30 mL/min) (27). According to post hoc analysis (17), the rate of major bleeding during fondaparinux administration was the highest in patients with moderate renal impairment, aged 75 years or more, and body weight less than 50 kg (35).…”

Section: Applications In Renal Dysfunction Patientsmentioning

confidence: 98%

“…One of the main advantages of fondaparinux is that its dosage does not need to be adjusted based on age or weight, because of its pharmacokinetics, namely, its specific binding to anti-thrombin and near 100% bioavailability (27). Fondaparinux with subcutaneous administration has a critically high bioactivity and is mainly excreted by the kidneys with a half-life of 17-21 h (45).…”

Section: The Advantages and Disadvantages Of Fondaparinuxmentioning

confidence: 99%

Pharmacological effects and clinical applications of ultra low molecular weight heparins

Liu

Sheng-li

Sheng

et al. 2014

DD&T

View full text Add to dashboard Cite

Heparin, one of the common anticoagulants, is clinically used to prevent and treat venous thromboembolism (VTE). Though it has been the drug of choice for many advanced medical and surgical procedures with a long history, the adverse events, such as bleeding, heparin-induced thrombocytopenia (HIT), allergic reactions, follow. Therefore, low molecular weight heparins (LMWHs) and ultra low molecular weight heparins (ULMWHs), with lower molecular weights, higher anti-FXa activity, longer half-life times and lower incidence of adverse events than unfractionated heparin (UFH), were researched and developed. Fondaparinux, a chemically synthesized ULMWH of pentasaccharide, has the same antithrombin III (AT-III)-binding sequence as found in UFH and LMWH. In addition, AVE5026 and RO-14, another two ULMWHs, are obtained by selective chemical depolymerization. In this paper, we review the preparation process, pharmacological effects and clinical applications of fondaparinux, AVE5026 and RO-14.

show abstract

“…The efficacy of low-molecular-weight heparins (LMWH) [ 10 , 11 ] and fondaparinux [ 12 , 13 ] for VTE prophylaxis has been established in major orthopedic surgery patients. However, there are a few cases of massive bleeding (MB) in patients receiving LMWH or fondaparinux [ 14 – 16 ]. Direct oral anticoagulants (DOACs) including both direct factor Xa inhibitors (rivaroxaban, apixaban and edoxaban) and the direct thrombin inhibitor (dabigatran) have shown a non-inferior effect for VTE prophylaxis compared to conventional prophylaxis [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

et al. 2017

View full text Add to dashboard Cite

BackgroundMeasurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).MethodsThe anti-Xa activity was measured one hour after edoxaban intake using 3 different assays in 200 patients after major orthopedic surgery.ResultsThe anti-Xa activities on Day 8 were significantly higher than those on Day 4 and those on Day 4 were significantly higher than those on Day 1. The anti-Xa activities in two assays closely correlated with each other, but the other anti-Xa assay did not correlated with other two assays. The anti-Xa activities as detected in the three Xa assays were significantly higher in the patients without deep vein thrombosis (DVT) than in those with DVT on Day 4. Additionally, there were no significant differences in the anti-Xa activities of assays A, B and C between patients with and without massive bleeding (MB) on Days 1, 4, 8 and 15.ConclusionThe results of this study suggest that anti-Xa level could be predictive of the risk of VTE, but not of the risk of massive bleeding.

show abstract

Compartment Syndrome Due to Massive Leg Hematoma After Primary Total Hip Arthroplasty

Cited by 10 publications

References 8 publications

Two Classifications for Surgical Wound Hematoma After Total Hip Replacement

Two Classifications for Surgical Wound Hematoma After Total Hip Replacement

Pharmacological effects and clinical applications of ultra low molecular weight heparins

Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

Contact Info

Product

Resources

About