Compartmental origins of striatal efferent projections in the cat

Jiménez‐Castellanos, J.; Graybiel, Ann M.

doi:10.1016/0306-4522(89)90080-8

Cited by 153 publications

(92 citation statements)

References 52 publications

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“…The projection neurons from the dorsal striatum to the VTA and SNPC are of particular interest. These projection neurons are contained within the patch compartments of the patch-and-matrix structure of the dorsal striatum, which are well known for their high levels of MOR expression (Jimenez-Castellanos and Graybiel, 1989;Desban et al, 1993). MOR in these compartments is predominantly extrasynaptic and responds to enkephalin released locally to modulate neuronal activity (Wang et al, 1996;Steiner and Gerfen, 1998).…”

Section: Neuroanatomical Connections Between Dorsal and Ventral Striatummentioning

confidence: 99%

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Burkett

Spiegel

Inoue

et al. 2011

Neuropsychopharmacol

112

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Despite significant evidence that opioids are involved in attachment by mediating social reward and motivation, the role of opioids in the formation of adult social attachments has not been explored. We used the socially monogamous prairie vole (Microtus ochrogaster) to explore the role of endogenous opioids in social bonding by examining partner preference formation in female prairie voles. We hypothesized that m-opioid receptors (MORs) in the striatum have a critical role in partner preference formation. We therefore predicted that peripheral administration of an opioid receptor antagonist would inhibit partner preference formation, and more specifically, that m-opioid selective receptor blockade within the striatum would inhibit partner preference formation. To test our hypotheses, we first administered the non-selective opioid antagonist naltrexone peripherally to females during an 18-h cohabitation with a male and later tested the female with a partner preference test (PPT). Females showed a dose schedule-dependent decrease in partner preference in the PPT, with females in the continuous dose group displaying stranger preferences. Next, we administered microinjections of the MOR selective antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) into either the nucleus accumbens shell (NAS) or the caudate-putamen (CP) immediately before a 24-h cohabitation with a male, and later tested the female with a PPT. Females receiving CTAP into the CP, but not the NAS, showed no preference in the PPT, indicating an inhibition of partner preference formation. We show here for the first time that MORs modulate partner preference formation in female prairie voles by acting in the CP.

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Section: Neuroanatomical Connections Between Dorsal and Ventral Striatummentioning

confidence: 99%

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Burkett

Spiegel

Inoue

et al. 2011

Neuropsychopharmacol

112

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“…In rat, cat, and primate, striosomes receive input primarily from prefrontal cortex, insular cortex, and amygdala, whereas the major projection to matrix is from association and sensorimotor cortex (2,27,28). Within the feline and rat neostriatum, interneurons may function to allow striosomal/matrix interactions (29-31).Separate striatal circuitry is preserved for efferent connections of striatum, with striosomal neurons projecting mainly to the substantia nigra pars compacta (SNc) and the majority of matrix neurons projecting to the globus pallidus pars externa (GPe), the globus pallidus pars interna (GPi), and substantia nigra pars reticulata (SNr) in rat (2, 4, 13, 31, 32), cat (10, 33), and primate (6,8,34,35). Striatal projection neurons contain y-aminobutyric acid as a neurotransmitter but may be differentiated by the presence or absence of neuropeptides such as substance P, dynorphin, and enkephalin (33,36,37 …”

mentioning

confidence: 99%

“…Separate striatal circuitry is preserved for efferent connections of striatum, with striosomal neurons projecting mainly to the substantia nigra pars compacta (SNc) and the majority of matrix neurons projecting to the globus pallidus pars externa (GPe), the globus pallidus pars interna (GPi), and substantia nigra pars reticulata (SNr) in rat (2,4,13,31,32), cat (10,33), and primate (6,8,34,35). Striatal projection neurons contain y-aminobutyric acid as a neurotransmitter but may be differentiated by the presence or absence of neuropeptides such as substance P, dynorphin, and enkephalin (33,36,37 (42) or predominantly in striosomes (19,43), and in human, cholinergic Ml binding sites (25) have been reported to be increased in striosomes relative to matrix.…”

mentioning

confidence: 99%

Compartmentalization of excitatory amino acid receptors in human striatum.

Dure

Young

Penney

1992

Proc. Natl. Acad. Sci. U.S.A.

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Division of the mammalian neostriatum into two intermingled compartments called striosomes and matrix has been established by analysis of enzyme activity, neuropeptide distribution, nucleic acid hybridization, and neurotransmitter receptor binding. Striosomes and matrix are distinct with respect to afferent and efferent connections, and these regions provide the potential for modulation and integration of information flow within basal ganglia circuitry. The primary neurotransmitters of corticostriatal afferents are excitatory amino acids, but to date no correlation of excitatory amino acid receptors and striatal compartments has been described. We examined binding to the three pharmacologically distinct ionotropic excitatory amino acid receptors, N-methyl-D-aspartate, a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid, and kainate, in human striatum using in vitro receptor autoradiography and compared the binding to striosomes and matrix histochemically dermed by acetylcholinesterase activity. Our findings reveal increased binding to N-methyl-D-aspartate receptors and a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in matrix relative to striosomes and increased kainate receptor binding in striosomes relative to matrix. These results suggest that afferent input to the two striatal compartments may be mediated by pharmacoloically distinct excitatory amino acid receptor subtypes.The mammalian neostriatum, composed of the caudate nucleus and putamen, participates in the modulation ofneuronal activity associated with cognitive, affective, and performance aspects of motor function. Abundant corticostriatal afferents from frontal, limbic, and primary sensorimotor cortex subserve these distinct but interrelated functions. Striatal efferents projecting to globus pallidus (GP) and substantia nigra (SN) integrate and modulate motor activities via direct and indirect pallidal motor circuits that ultimately project back to cerebral cortex. Recent evidence suggests that the neostriatum is able to maintain segregated information flow due to compartmentalization in mammalian caudate and putamen (1-11). Distinct regions within caudate and putamen have been defined in several species with histochemical techniques, in situ hybridization, and neurotransmitter receptor binding studies in rat (1,(12)(13)(14)(15), cat (10, 14, 16-20), primate (12, 14, 19-22), and human (20,(23)(24)(25)(26). These compartments, termed striosomes and matrix, exhibit distinct afferent and efferent connections. In rat, cat, and primate, striosomes receive input primarily from prefrontal cortex, insular cortex, and amygdala, whereas the major projection to matrix is from association and sensorimotor cortex (2,27,28). Within the feline and rat neostriatum, interneurons may function to allow striosomal/matrix interactions (29-31).Separate striatal circuitry is preserved for efferent connections of striatum, with striosomal neurons projecting mainly to the substantia nigra pars compacta (SNc) and the majority of matrix neurons projec...

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“…However, it should be noted that previous de scriptions of these projections have been based on different tra cing techniques, i.e. the anterograde tridated amino acid tracing [26,27 ] or retrograde tracing [ 42]. It is possible that PI-IA-L and BDA used in the present study, are less suitable to visualize small calibre mesostriatal liber systems over such long distances in cats.…”

Section: Rrn-efferents To the Telencephalonmentioning

confidence: 90%

“…As such, the A8 cell group can control the activity in these two striatal domains. Fourth, both the projections from the SNC to the dorsal striatum and the projections from the VTA to the ventral striatum are reciprocal [24,27,35], suggesting that the A9 and A 10 nuclei receive direct feedback from their respective target areas in the striatum. In contrast, the dorsal striatal A8-innervated region has no projection back to the A8 cell group, implying that there does not exist such a feedback loop [19,20,27,30,37, see however ref.…”

Section: Introductionmentioning

confidence: 99%

Efferent projections of the retrorubral nucleus to the substantia nigra and ventral tegmental area in cats as shown by anterograde tracing

Arts

Groenewegen²,

Veening

et al. 1996

Brain Research Bulletin

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The aim of the present study was to determine whether the retrorubral nucleus projects to the dopaminergic nuclei in the ventral midbrain of the cat. For this purpose, injec tions of biotinylated dextran-amine or Phaseolus vulgaris-leucoagglutinin were placed into the retrorubral nucleus under ste reotaxic guidance. The tracers were visualized by means of (immune) histochemical procedures. In addition, tyrosine hy droxylase immunohistochemistry was used to evaluate the lo cation of the injection sites and the distribution of the anterogradely labeled fibers. Both tracers reveal the same topography of labeled fibers in the ventral mesencephalon. Labeled fibers with varicosities were found ipsilaterally in the substantia nigra pars compacta, the substantia nigra pars lateralis, the ventral tegmental area and, contralaterally, In the substantia nigra pars compacta* the ventral tegmental area, and the retrorubral nu cleus, A considerable number of labeled axons with varicosities were observed to be wrapped around the dendrites and perikarya of tyrosine hydroxylase-positive neurons in these areas. The present results are discussed in view of the possible role of the A8 dopaminergic cell group in the coordination of A9 nigrostriatal and A10 mesolimbic systems, as well as in the progres sive pathology seen In patients suffering from Parkinson's dis ease.KEY WORDS: A8, A9, A10, Dopamine, Tyrosine hydroxylase im munohistochemistry, Phaseolus vulgaris-leucoagglutinin, Bioti nylated dextran-amine.

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Compartmental origins of striatal efferent projections in the cat

Cited by 153 publications

References 52 publications

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Compartmentalization of excitatory amino acid receptors in human striatum.

Efferent projections of the retrorubral nucleus to the substantia nigra and ventral tegmental area in cats as shown by anterograde tracing

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