In Australia, there is a growing concern about the well-being of teachers with many expressing their intention to leave the profession or indeed have already left. Various reasons have been suggested for this trend, with burnout being identified as one of the factors. This study investigates burnout in Australian teachers as one of the constructs which make up compassion fatigue (CF), a reduced ability to empathise with others. Moreover, it explores secondary traumatic stress (STS), which also contributes to CF and occurs when a person learns about the traumatic experiences of someone under their care. Both constructs may severely impact the ability of teachers to form close relationships with their students. As part of the present study, 1939 Australian teachers were surveyed about their quality of life, well-being, classroom efficacy, and trauma awareness. Findings demonstrate that teachers with higher levels of well-being and with higher perceived classroom efficacy are less prone to burnout, reducing the risk of emotional exhaustion and disengagement often associated with this phenomenon. Conversely, connections were found between lower well-being of teachers and educators' awareness of trauma and their susceptibility to STS. Recommendations are made for further research exploring the barriers and enablers of compassion fatigue as well as positive teacher well-being, in order to develop targeted initiatives to better prepare and protect teachers to work with a cohort of students who are increasingly demonstrating symptoms of trauma and poor well-being.