Compassionate embryo transfer: physician practices and perspectives

Hairston, Jacqueline C.; Kohlmeier, Amanda; Feinberg, Eve C.

doi:10.1016/j.fertnstert.2020.04.026

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…Hairston et al present results from a cross-sectional survey of members of the Society for Reproductive Endocrinology and Infertility (SREI) exploring attitudes and practice related to ''compassionate transfer'' of frozen embryos (1). The practice of compassionate transfer is ''the intentional placement of embryo(s) into the female reproductive tract.when implantation is unlikely to occur'', that is, a transfer done with the explicit goal of not establishing a pregnancy.…”

Section: Compassionate Embryo Transfer: Part Of a Bigger Questionmentioning

confidence: 99%

Compassionate embryo transfer: part of a bigger question

Monseur

Alvero

Schlaff

2020

Fertility and Sterility

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Section: Compassionate Embryo Transfer: Part Of a Bigger Questionmentioning

confidence: 99%

Compassionate embryo transfer: part of a bigger question

Monseur

Alvero

Schlaff

2020

Fertility and Sterility

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“…A particular concern in ART practice arises from embryo freezing, which leads to a growing number of embryos stored in cryobanks for an indefinite period of time. Indeed, there was a sharp increase in the United States (U.S.) from 2004 to 2013 of ART cycles in which all embryos have been frozen, and this resulted in a higher and increasing number of embryos stored [ 37 ], estimated to be 600,000 (or more) in the U.S. alone [ 38 ]. Concern about this topic can arise also in some countries where this practice is not allowed.…”

Section: Introductionmentioning

confidence: 99%

Assisted Reproductive Technology without Embryo Discarding or Freezing in Women ≥40 Years: A 5-Year Retrospective Study at a Single Center in Italy

Manna

Barbagallo

Sagnella³

et al. 2023

JCM

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The protocols commonly used in assisted reproductive technology (ART) consist of long-term embryo culture up to the blastocyst stage after the insemination of all mature oocytes, the freezing of all the embryos produced, and their subsequent transfer one by one. These practices, along with preimplantation genetic testing, although developed to improve the live birth rate (LBR) and reduce the risk of multiple pregnancies, are drawing attention to the possible increase in obstetric and perinatal risks, and adverse epigenetic consequences in offspring. Furthermore, ethical–legal concerns are growing regarding the increase in cryopreservation and storage of frozen embryos. In an attempt to reduce the risk associated with prolonged embryo culture and avoid embryo storage, we have chosen to inseminate a limited number of oocytes not exceeding the number of embryos to be transferred, after two days or less of culture. We retrospectively analyzed 245 ICSI cycles performed in 184 infertile couples with a female partner aged ≥40 from January 2016 to July 2021. The results showed a fertilization rate of 95.7%, a miscarriage rate of 48.9%, and a LBR of 10% with twin pregnancies of 16.7%. The cumulative LBR in our group of couples was 13%. No embryos were frozen. In conclusion, these results suggest that oocyte selection and embryo transfer at the cleaving stage constitute a practice that has a LBR comparable to that of the more commonly used protocols in older women who have reduced ovarian reserve.

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“…Patients may be subject to undue pressure to transfer genetically abnormal embryos, or physicians may be held liable if they perform embryo transfer outside of the implantation window. 4 As a result, patients may seek to transfer embryos to another state. “Aiding and abetting” penalties may apply, and facilities may not want to take the risk of accepting these embryos for either destruction or research.…”

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confidence: 99%