Compatibility of common <scp>IV</scp> drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin

Heiderich, Sebastian; Springe, Anna auf der; Jürgens, Jonas; Koppert, Wolfgang; Leffler, Andreas; Sümpelmann, Robert; Dennhardt, Nils

doi:10.1111/pan.13309

Cited by 2 publications

(5 citation statements)

References 6 publications

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“…In this study, only minor changes in OD were observed, which did not exceed the control experiments, whereas in previous studies, incompatible drug-infusion mixtures showed an increase of up to 6.91 times the initial OD. 5,6 Therefore, we conclude that no major incompatibility reactions occurred in this study.…”

Section: Turbidimetric Measurementssupporting

confidence: 48%

“…However, significant changes in electrical conductivity rarely occur in compatibility testing. 5,6 In this study, slight changes were detected initially when adding glucose to Sterofundin ISO. This confirms the idea that a change of molecules in solution (glucose in this case) may change the electrical conductivity of the same solution.…”

Section: Electrical Conductivitymentioning

confidence: 66%

“…The infusion solutions with added glucose were tested in an in vitro experiment for physical and chemical stability, as previously reported. 5,6 Electrical conductivity, turbidity, pH, and visual macroscopic examination were assessed. The measurements were taken from 20-mL samples of the infusion solutions immediately after adding glucose, after 24 hours, and after 1 week in a temperature-and humidity-controlled environment at room temperature.…”

Section: Methodsmentioning

confidence: 99%

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Stability of 0.5% Glucose-Containing Balanced Electrolyte Solutions for Patients on Ketogenic Diets: A Laboratory Study

et al. 2020

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Purpose Ketogenic diets (KDs) are used to treat epilepsies resistant to pharmacotherapy or some inborn errors of metabolism. For prolonged anesthesia, use of balanced electrolyte solutions (BESs) supplemented with 0.5% glucose has been advocated to maintain ketosis while preventing hypoglycemia. Unfortunately, there is no BES containing 0.5% glucose available from pharmacies. In a laboratory study, we investigated the physical and chemical stability of different BES mixtures containing 0.5% glucose. Methods In total, six approaches were chosen to create a BES with 0.5% glucose: three different glucose-free BESs were supplemented with glucose. Additionally, commercially available BES containing 1% glucose was diluted with three different glucose-free BESs to obtain a solution containing 0.5% glucose. Turbidity, pH, electrical conductivity, and macroscopic appearance of these solutions were measured immediately, at 24 hours, and after 7 days, and were compared with the original BES. Results Turbidity, pH, and electrical conductivity, as well as macroscopic appearance did not exceed the changes of the controls. Conclusions No signs of incompatibility reactions could be observed in a 1-week time period. Our study supports the stability of the examined BES containing 0.5% glucose for prolonged anesthesia in patients on KD. Clinical studies are needed to evaluate if BES containing 0.5% glucose is superior in patients on KDs.

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Section: Turbidimetric Measurementssupporting

confidence: 48%

Section: Electrical Conductivitymentioning

confidence: 66%

Section: Methodsmentioning

confidence: 99%

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Stability of 0.5% Glucose-Containing Balanced Electrolyte Solutions for Patients on Ketogenic Diets: A Laboratory Study

et al. 2020

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“…Meropenem was also tested in combination with gelatine 4% (compatible) and hydroxyethyl starch (pH change observed) as infusion solutions. 19 However, only a period of 1 h was observed in that study. In our study, incompatibility occurred after a time period of more than 1 h. Therefore, meropenem should not be mixed with both electrolyte solutions and acetaminophen.…”

Section: Laboratory Findingsmentioning

confidence: 70%

“…Heiderich et al 18 indicated meropenem as compatible with two isotonic electrolyte solutions (Sterofundin and E148G1 Paed). Meropenem was also tested in combination with gelatine 4% (compatible) and hydroxyethyl starch (pH change observed) as infusion solutions 19 . However, only a period of 1 h was observed in that study.…”

Section: Discussionmentioning

confidence: 99%

Y‐site administration of electrolyte solutions and injectable acetaminophen—A physical compatibility study with combinations frequently used in pediatric intensive care and anesthesia

Kleinlein¹,

Marschler²,

Neininger

et al. 2022

Pediatric Anesthesia

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Aim Determination of the physical compatibility of acetaminophen and two different electrolyte solutions (an isotonic, balanced electrolyte solution and a hypotonic, glucose containing electrolyte solution) with drugs frequently used in routine pediatric intensive care. Methods Analytical investigations for frequently used combinations without pre‐existing data were performed. Visual and microscopic observations according to the European Pharmacopeia as well as pH measurements and ultraviolet visible spectrometry at wavelengths of 350, 410 and 550 nm were conducted to analyze physical compatibility. All measurements were performed immediately after mixing as well as 1, 4, and 24 h after. Results In total, 42 combinations were analyzed. Visual incompatibilities were found with pantoprazole and diazepam with both electrolyte solutions. For furosemide, a particle formation in mixture with the hypotonic glucose‐containing electrolyte solution and a change in pH ≥ 0.5 after 24 h with both electrolyte solutions were observed. Ampicillin, cefuroxime, diazepam, furosemide, linezolid, meropenem, and pantoprazole showed an aberration of the absorbance ≥0.04 (350 nm/410 nm) or ≥0.01 (550 nm) in the photometric measurements with the electrolyte solutions. For acetaminophen, a physical incompatibility was observed with ampicillin, diazepam, furosemide, and pantoprazole. Conclusion Most of the analyzed combinations showed no signs of physical incompatibility and may therefore be administered via the same Y‐site. However, diazepam, furosemide, and pantoprazole should not be administered simultaneously with acetaminophen or both electrolyte solutions.

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Compatibility of common IV drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin

Cited by 2 publications

References 6 publications

Stability of 0.5% Glucose-Containing Balanced Electrolyte Solutions for Patients on Ketogenic Diets: A Laboratory Study

Stability of 0.5% Glucose-Containing Balanced Electrolyte Solutions for Patients on Ketogenic Diets: A Laboratory Study

Y‐site administration of electrolyte solutions and injectable acetaminophen—A physical compatibility study with combinations frequently used in pediatric intensive care and anesthesia

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