Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

Abstract

Application of thermogravimetry (TG) alone to study compatibility/incompatibility of active pharmaceutical ingredients (APIs) with excipients yields to misleading results due to overlapping of the thermal stages in the course of decomposition of both ingredients and their pharmaceutical mixtures. Hence, the purpose of this study was to assess the usefulness of multivariate statistical analysis as a supporting tool for interpretation of the TG traces during assessing compatibility of hydrocortisone as an API with selected excipients (mannitol, starch, lactose, methylcellulose, b-cyclodextrin, meglumine, chitosan, magnesium stearate and polyvinylpyrrolidone). The results show that two multivariate techniques, principal component analysis (PCA) and cluster analysis (CA), can be successfully used for interpretation of TG traces, while the TG is used alone as a screening technique to assess compatibility. The results obtained by using TG analysis, supported by PCA and CA, were approved by those of differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction. Incompatibilities were only found in mixtures of hydrocortisone with magnesium stearate and b-cyclodextrin.

Preparation and properties of organomineral adsorbent obtained by sol–gel technology

“…It should be noted that in case of inert atmosphere, such products as NO, NO 2 , CH 3 COCH 3 could be obtained by intramolecular oxidation or some chemical groups rearrangements. In Table 4, fixed ions placed on the descending intensity values according to MS and well correlated with literature data [56][57][58][59][60][61][62][63][64][65][66][67].…”

Compatibility Studies of Selected Mucolytic Drugs With Excipients Used in Solid Dosage Forms: Thermogravimetry Analysis

“…This indicates that there is no interaction between the tested API and the excipient. Other authors recorded a similar relationship for diclofenac sodium [20], indapamide [21], enalapril [24], hydrocortisone [25] confirmed by the other analytical methods like DSC, XRDP, FTIR. The TG/DTG curves recorded for the tested mucolytic drugs, lactose monohydrate and physical binary mixture API with lactose monohydrate in different weight ratio are presented in Figure 2.…”

Nanoantenna-assisted plasmonic enhancement of IR absorption of vibrational modes of organic molecules

“…The IR spectrum of cortisol reveals the most pronounced absorption bands associated with valence vibrations of C=O groups [ 42 – 43 ]. According to [ 44 ] the calculated (experimental) frequency positions of the bands are located at 1686 (1660) cm −1 and 1725 (1735) cm −1 and demonstrate the highest intensities. Therefore, the structural parameters of the nanoantennas were chosen in such a way to ensure the LSPR absorption band close to the energy of the most pronounced vibrational modes in cortisol.…”