Compatibility study of dry extract of Ximenia americana L. and pharmaceutical excipients used in solid state

Santana, Cleildo P.; Fernandes, Felipe Hugo Alencar; Brandão, Deysiane Oliveira; Silva, Paulo César D.; Correia, Lidiane Pinto; Nóbrega, Fernanda Pontes; Medeiros, Francinalva Dantas de; Diniz, Paulo Henrique Gonçalves Dias; Véras, Germano; Medeiros, Ana Cláudia Dantas de

doi:10.1007/s10973-017-6764-8

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…Between 788 and 674 cm − 1 , narrow peaks of a low intensity were visualized, probably related to C–H bonds in substituted aromatics. These chemical bonds refer to a variety of functional groups—such as ethers, esters, and carboxylic acids—that accompany the chemical composition of flavonoids, tannins, anthraquinones, and other secondary metabolites present in the extract [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…Santana et al (2018) characterized a hydroalcoholic extract of X. americana , and their results showed that it was possible to identify and quantify gallic acid as a chemical marker of X. americana . In addition, they developed X. americana tablets to combat antifungal and bacterial infections, highlighting the pharmacological potential of the species and its phytochemical components [ 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

et al. 2019

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The use of biocompatible polymers such as Hydroxypropylmethylcellulose (HPMC), Hydroxyethylcellulose (HEC), Carboxymethylcellulose (CMC), and Carbopol in solid formulations results in mucoadhesive systems capable of promoting the prolonged and localized release of Active Pharmaceutical Ingredients (APIs). This strategy represents a technological innovation that can be applied to improving the treatment of oral infections, such as oral candidiasis. Therefore, the aim of this study was to develop a tablet of Ximenia americana L. from mucoadhesive polymers for use in the treatment of oral candidiasis. An X. americana extract (MIC of 125 μg·mL−1) was obtained by turbolysis at 50% of ethanol, a level that demonstrated activity against Candida albicans. Differential Thermal Analysis and Fourier Transform Infrared Spectroscopy techniques allowed the choice of HPMC as a mucoadhesive agent, besides polyvinylpyrrolidone, magnesium stearate, and mannitol to integrate the formulation of X. americana. These excipients were granulated with an ethanolic solution 70% v/v at PVP 5%, and a mucoadhesive tablet was obtained by compression. Finally, mucoadhesive strength was evaluated, and the results demonstrated good mucoadhesive forces in mucin disk and pig buccal mucosa. Therefore, the study allowed a new alternative to be developed for the treatment of buccal candidiasis, one which overcomes the inconveniences of common treatments, costs little, and facilitates patients’ adhesion.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

et al. 2019

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“…As expected, the extract showed undesirable flow properties [ 6 ] ( Table 4 ), which may be due to its amorphous and hygroscopic characteristics (the dry extract presented a moisture content of 7.91% [ 11 ]), even in the presence of a drying adjuvant. This shows the need to incorporate lubricants and glidants into the formulation, in order to make the plant extract suitable for the direct compression method.…”

Section: Resultsmentioning

confidence: 76%

“…The tablet was developed after the compatibility study between the extract of X . americana (AMCA) and pharmaceutical excipients, as described by Santana et al [ 11 ]. Binary mixtures were prepared from physical mixtures of the extract with the following pharmaceutical excipients: corn starch, lactose, microcrystalline cellulose PH 101 and 102, magnesium stearate, polyvinyl pyrrolidone K-30 (PVP K-30), talc, colloidal silicon dioxide, sodium starch glycolate, pregelatinized starch, and sodium croscarmellose.…”

Section: Methodsmentioning

confidence: 99%

Dissolution and uniformity of content of tablets developed with extract of Ximenia americana L.

et al. 2018

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Herbal medicines currently represent an important part of the world pharmaceutical market, which shows growing interest in the use of herbal medicines. However, the production of such medicines involves a complex series of steps, which determine the production viability and the quality of the final product. Ximenia americana L. is a plant occurring in several regions of the world, with well-known and applied medicinal properties. Thus, the aim of this work was to develop and evaluate the physical and physical-chemical quality of tablets produced with X. americana L. extract. The extract was spray-dried from a hydroethanolic extractive solution and characterized as to its phytochemical composition. The chemical marker was determined and quantified using validated chromatographic methods. These methods indicated the presence of gallic acid at a concentration of 1.61 mg g-1. Formulations were proposed and analyzed for their flow and compaction properties. The best formulation was used to obtain a batch of tablets, which was evaluated for its quality characteristics and showed to be within the pharmacopoeial specifications for average weight, hardness, friability, and disintegration time. The dissolution profile of the tablets produced was obtained, showing the release of about 70% of the vegetable extract content within 30 minutes. Results showed that it was possible to obtain herbal tablets containing a high content of vegetal extract by direct compression, developing a rapid process of formulation and production and guaranteeing the quality characteristics of the final product.

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“…In the FTIR spectrum related to the powder extract, there is broadband with peaks at 3391 and 3213 cm -1 , obviously resulting from superimposed O-H and NH 3+ stretches (Silverstein, Webster, Kiemle, 2005). In this case, hydroxyl groups are attributed both to hydroxylated molecules of the extract (such as polyphenols) and to the moisture content of the extract (Santana et al 2018), while NH 3+ stretch band is attributed to L-arginine. The sharp peaks at 2920 and 2852 cm -1 are characteristic of carbon-hydrogen bonds (Silverstein, Webster, Kiemle, 2005).…”

Section: Resultsmentioning

confidence: 99%

Assessing compatibility of excipients selected for a sustained release formulation of bilberry leaf extract

Kolisnyk

Vashchenko

Рубан

et al. 2022

Braz. J. Pharm. Sci.

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The study is aimed to assess the compatibility of bilberry leaf powder extract (BLPE) with six excipients selected for sustained-release (SR) tablet formulation. The BLPE was obtained with the addition of L-arginine and Myo-inositol as the carriers. Thermogravimetric (TG-DTG) analysis and Fourier-transform infrared spectroscopy (FTIR), supported by Pearson correlation analysis, were applied to detect possible interactions in the binary mixtures (1:1) of the BLPE with each excipient. The TG-DTG showed some deviations in the thermal behavior of the BLPE / excipient mixtures. However, only the thermal behavior of magnesium stearate in the mixture significantly differed from individual samples, which suggested chemical interaction for this excipient. The FTIR analysis confirmed that the BLPE is compatible with Eudragit L100, Methocel K4M, Methocel K100LV, Avicel PH-101, and Plasdone S-630. Whereas it undergoes solid-state chemical interaction in the binary mixture with magnesium stearate. According to the FTIR-spectra, it is suggested that this interaction results in the formation of stearic acid and alkalization of the medium. These findings evidence for the possibility of using TG-DTG analysis as an independent thermal technique for compatibility studies and also confirm the earlier reported interaction of basic lubricants, e.g., stearic salts, with active ingredients containing amino groups.

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Compatibility study of dry extract of Ximenia americana L. and pharmaceutical excipients used in solid state

Cited by 11 publications

References 31 publications

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

Dissolution and uniformity of content of tablets developed with extract of Ximenia americana L.

Assessing compatibility of excipients selected for a sustained release formulation of bilberry leaf extract

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