Compatibility study of hydroxychloroquine sulfate with pharmaceutical excipients using thermal and nonthermal techniques for the development of hard capsules

Liquid Chromatographic Methods for COVID-19 Drugs, Hydroxychloroquine and Chloroquine

“…Whole blood from samples were diluted with water to lyse the erythrocytes and alkalized to increase the recovery; however, obtained recoveries were very low as between 25 and 60% compared to other techniques ( 46 ). The compatibility of HCQ with tablet excipients was evaluated using thermal and nonthermal stress testing including sample storage during a month under 75% RH and 40°C conditions and the developed LC-FL method was conducted for quantification ( 35 ). HCQ was determined in breast milk samples obtained from 33 patients after administration of 200–400 mg doses.…”

“…LC-based methods are primarily applied separation techniques for the analysis of CQ and HCQ as well as their metabolites from whole blood, plasma and/or pharmaceutical preparations. Different types of reversed-phase columns were used such as C18 ( 5 , 6 , 35 , 38 , 40 , 41 , 43 , 44 , 46 , 50–52 , 58–61 , 70 ), C8 ( 33 , 34 , 36 , 53 ), CN ( 37 , 54 ), HILIC ( 45 ) and phenyl ( 42 ); however, C18 was the most used one. C18, C8 and octadecyl groups, including silica, can contribute to prevent sacrificing the peak shapes for CQ, HCQ and related metabolites.…”

“…Several different wavelengths were used for the UV detection such as 254 nm ( 53 ), 343 nm ( 5 , 54 ), 240 nm ( 61 ), 254 nm ( 58 ), 343 nm ( 5 ), 331 nm ( 51 ), 256 nm ( 38 ), 260 nm ( 59 ), 250 nm ( 60 ) as well as different flow rates 0.8 mL ( 53 , 61 ), 1.0 mL ( 38 , 51 , 58–60 ), 1.2 mL ( 54 ) and 2.0 mL ( 5 ). Fluorimetric detections were performed using 335 nm ( 40 ), 320 nm ( 46 ), 325 nm ( 35 ), 337 nm ( 41 ), 320 nm ( 42 ) for excitation and 390 nm ( 40 ), 370 nm ( 46 ), 375 nm ( 35 ), 371 nm ( 41 ) 380 nm ( 42 ) for emission wavelengths, respectively. Ambient temperature as well as 40°C ( 40 , 46 ), 50°C ( 42 ) were used as column temperature to obtain better separation of analytes of interest.…”

Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19

“…These TGA and DSC findings were consistent with a recent report on a crystalline form of HCQ. (42) The vapor sorption assessment by DVS showed that HCQ-sul started to uptake a huge amount of moisture at 85% RH and it eventually deliquesced. Up to 80% RH, there was only a minor change in weight, that is, below 1% due to moisture uptake.…”

Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review

“…On the other hand, the glass transition point ( T g ) describes the temperature at which the mechanical properties of a material change from hard and brittle to soft, deformable or rubbery [ 94 ]. In addition, a new peak in FTIR spectroscopy can represent bond formation in a crosslinked system that may result in the change in T m and/or T g in DSC analysis [ 95 ]. On the other hand, TGA measures the mass change of a material during a process, such as decomposition, due to the temperature change, in accordance with ASTM E1131-08 [ 96 ].…”