Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response

Luo, Yusha; Zhang, Xing-Jie; Wen, Zhang; Yang, Qiliang; Wang, You; Wen, Jing; Zhou, Tingting

doi:10.1016/j.phymed.2021.153656

Cited by 16 publications

(15 citation statements)

References 45 publications

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“…In addition, SCFAs also play a role in the models of hepatotoxicity. For example, butyrate has a detoxification effect on a genipin-induced liver injury by promoting colonic integrity and promoting Nrf2 activation (Luo et al, 2021 ). A study by Mun et al ( 2021 ) showed that an SCFA mixture treatment improved metabolic activation of liver organoids and contributed to the accurate evaluation of the CYP3A4-dependent drug toxicity.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats

Li²,

Lu³

et al. 2022

Front. Microbiol.

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In recent years, many reports focus on the hepatotoxicity of Gynura segetum root extract (GSrE), but the interaction between GSrE and the gut microbiota is still unclear. This study investigated the mechanism of GSrE-induced hepatotoxicity of different doses and exposure durations by combining metabolomics and gut microbiota analysis. SD rats were divided into 3 groups: blank, low-dose (7.5 g/kg), and high-dose (15 g/kg) groups. Urine and feces samples were collected on day 0, day 10, and day 21. Metabolomics based on gas chromatography-mass spectrometry (GC-MS) was carried out to identify metabolites and metabolic pathways. 16S rDNA gene sequencing was applied to investigate the composition of gut microbiota before and after GSrE-induced hepatotoxicity. Finally, a correlation analysis of metabolites and gut microbiota was performed. Differential metabolites in urine and feces involved amino acids, carbohydrates, lipids, organic acids, and short chain fatty acids. Among them, L-valine, L-proline, DL-arabinose, pentanoic acid, D-allose, and D-glucose in urine and D-lactic acid and glycerol in fecal metabolites depended on the exposure of time and dose. In addition, 16S rDNA sequencing analysis revealed that GSrE-induced hepatotoxicity significantly altered the composition of gut microbiota, namely, f_Muribaculaceae_Unclassified, Lactobacillus, Bacteroides, Lachnospiraceae_NK4A136_group, f_Ruminococcaceae_Unclassified, Prevotellaceae_Ga6A1_group, and Escherichia-Shigella. The correlation analysis between gut microbiota and differential metabolites showed the crosstalk between the gut microbiota and metabolism in host involving energy, lipid, and amino acid metabolisms. In summary, our findings revealed that peripheral metabolism and gut microbiota disorders were time- and dose-related and the correlation between gut microbiota and metabolites in GSrE-induced hepatotoxicity.

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Section: Discussionmentioning

confidence: 99%

Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats

Li²,

Lu³

et al. 2022

Front. Microbiol.

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“…When the gut microbiota was depleted, the disappearance of VTE efficacy verified its targeted regulatory mechanism on the gut microbiota. A TCM composed of Gardeniae Fructus and Semen Sojae Praeparatum, named Zhizichi Decoction, was found to reduce liver injury by regulating the gut microbiota population, promoting butyric acid production and activating the antioxidant reaction ( 48 ). In addition, Ganshuang Granules [composed of Chinese herbs such as Radix Codonopsis, Bupleurum Falcatum and Salviae Miltiorrhiza] can rebalance the gut microbiota and reduce intestinal permeability, thereby reducing oxidative stress and inflammation and ultimately ameliorating CCl 4 -induced hepatotoxicity and ALI ( 49 ).…”

Section: Targeting Gut Microbiota For Acute Liver Injurymentioning

confidence: 99%

Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

Zhu

Zheng

et al. 2023

Front. Immunol.

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The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune liver disease and liver cancer. Given the therapeutic status of these diseases, their prevention and early therapy are crucial, and the detailed mechanism of gut microbiota in liver disease urgently needs to be explored. Meanwhile, multiple studies have shown that various traditional Chinese medicines, such as Si Miao Formula, Jiangzhi Granules, Liushen Capsules, Chaihu-Shugan Power, Cassiae Semen and Gynostemma, as well as some natural products, including Costunolide, Coprinus comatus polysaccharide, Antarctic krill oil, Oridonin and Berberine, can repair liver injury, improve fatty liver, regulate liver immunity, and even inhibit liver cancer through multiple targets, links, and pathways. Intriguingly, the aforementioned effects demonstrated by these traditional Chinese medicines and natural products have been shown to be closely related to the gut microbiota, directly driving the strategy of traditional Chinese medicines and natural products to regulate the gut microbiota as one of the breakthroughs in the treatment of liver diseases. Based on this, this review comprehensively summarizes and discusses the characteristics, functions and potential mechanisms of these medicines targeting gut microbiota during liver disease treatment. Research on the potential effects on gut microbiota and the regulatory mechanisms of traditional Chinese medicine and natural products provides novel insights and significant references for developing liver disease treatment strategies. In parallel, such explorations will enhance the comprehension of traditional Chinese medicine and natural products modulating gut microbiota during disease treatment, thus facilitating their clinical investigation and application.

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“…Meanwhile, the enrichment of SCFAs by Gardeniae fructus had a certain mitigating effect on the hepatotoxic substances in Chinese medicine. 221 Andrographolide, increases the level of SCFAs and alleviates LPSinduced oxidative stress by limiting the overproduction of ROS and superoxide anion radicals. 210 TMAO and LPSlike stimulators induce of M1 macrophage polarization 222 and the activation of PERK.…”

Section: Influence Probiotics or Strains With Specific Metabolitesmentioning

confidence: 99%

“…The herbal pairs (e.g., Sophorae japonica and Gardenia Jasminoides 219 ) and compounds (e.g., Gegen qinlian decoction 220 ) that affect SCFAs are more comprehensive and in‐depth. Meanwhile, the enrichment of SCFAs by Gardeniae fructus had a certain mitigating effect on the hepatotoxic substances in Chinese medicine 221 . Andrographolide, increases the level of SCFAs and alleviates LPS‐induced oxidative stress by limiting the overproduction of ROS and superoxide anion radicals 210 .…”

Section: The Interrelationship Between Tcm and Intestinal Bacteriamentioning

confidence: 99%

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Zou,

Wang,

Zhang

et al. 2023

Medicinal Research Reviews

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Over the past decade, colorectal cancer has reported a higher incidence in younger adults and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation, progression, and treatment of colorectal cancer has been extensively studied, as well as their positive therapeutic impact on inflammation and the cancer microenvironment. Historically, traditional Chinese medicine (TCM) has been widely used in the treatment of colorectal cancer via promoted cancer cell apoptosis, inhibited cancer metastasis, and reduced drug resistance and side effects. The present research is more on the effect of either herbal medicine or intestinal flora on colorectal cancer. The interactions between TCM and intestinal flora are bidirectional and the combined impacts of TCM and gut microbiota in the treatment of colon cancer should not be neglected. Therefore, this review discusses the role of intestinal bacteria in the progression and treatment of colorectal cancer by inhibiting carcinogenesis, participating in therapy, and assisting in healing. Then the complex anticolon cancer effects of different kinds of TCM monomers, TCM drug pairs, and traditional Chinese prescriptions embodied in apoptosis, metastasis, immune suppression, and drug resistance are summarized separately. In addition, the interaction between TCM and intestinal flora and the combined effect on cancer treatment were analyzed. This review provides a mechanistic reference for the application of TCM and intestinal flora in the clinical treatment of colorectal cancer and paves the way for the combined development and application of microbiome and TCM.

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Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response

Cited by 16 publications

References 45 publications

Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats

Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats

Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

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