Compelling new data on the effectiveness of Australia's National Bowel Cancer Screening Program: A model for best practice?

John, James St; Grogan, Paul

doi:10.1111/ajco.12484

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Of the 297 378 participants with negative screening results, 176 (0.06%) had a false negative result, with cancer diagnosed over the following 2-year period. With the positive predictive value of 3.6%, the likelihood of harbouring bowel cancer is 60 times greater in those who are iFOBT-positive than negative 13 , an important point when considering efficient use of colonoscopy. More recent analysis (2018) of outcomes of participants from 2006 to 2010 showed similar findings to the earlier report.…”

Section: Screening Outcomesmentioning

confidence: 99%

The National Bowel Cancer Screening Program: time to achieve its potential to save lives

Ee¹,

John²

2019

Public Health Res Pract

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Objectives: Bowel cancer is the second most common cause of cancer deaths in Australia, affecting both men and women. The National Bowel Cancer Screening Program (NBCSP) began in 2006 with the aim of reducing the morbidity and mortality from bowel cancer in Australia. It is based on level I evidence of mortality reduction with screening using the faecal occult blood test (FOBT). Type of program or service: The NBCSP is a world-first national program using the immunochemical FOBT (iFOBT), beginning as a staged rollout limited to people aged 55 and 65 years. By 2020, rollout will be complete, with biennial screening for people aged between 50 and 74 years. The program is managed by the Australian Government Department of Health, in partnership with the states and territories. Methods: Mailing of iFOBT kits is organised through a national register and participants with a positive test are recommended for colonoscopy by the usual care pathway. Outcomes are reported to a national register, with the Australian Institute of Health and Welfare providing crucial support with data monitoring and analyses. This paper analyses the program's implementation and outcomes to date, and looks at whether it is on track to reach its full potential. Results: Program participants have been shown to have earlier cancer diagnoses and a 15% mortality reduction after accounting for lead-time bias. Modelling analyses predict that increasing participation from the current 41% will result in further reductions in mortality and improvements in cost-effectiveness, which should eventually deliver net savings to the Australian Government. Lessons learnt: The initiation and success of the NBCSP has been founded on strong evidence, but there remain areas for improvement, including capture of outcomes data and timely colonoscopy access. On current evidence, increasing participation among the established 50-74-year-old cohort will yield the strongest investment in improved outcomes. Future technological change could present opportunities in risk-based, personalised prevention and screening. Expanding the age range, for example, by starting screening at 45 years, is currently under review. Importantly, maintenance and development of the program should be driven by strong evidence to ensure its ongoing success as a major Australian health initiative.

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Section: Screening Outcomesmentioning

confidence: 99%