Compendious Review on Adipokines of Corpulence

Abstract

Adipokines are biologically effective substances released by adipose tissue and contributed for the management of many biological processes such as food intake, energy spending, adipocyte growing, tissue susceptibility to insulin, function of endothelium and many others. The modes of action of adipokines are autocrine or paracrine in adipocyte and endocrine in other tissues such as muscles, liver, and brain. Therefore, abnormal actions or levels of many adipokines may act as vinculum between corpulence, or cellular injury, and insusceptibility to insulin. Hereafter, the guidelines for the treatment of corpulence and related metabolic disorders may focus on the uses of drugs with adipokines agonist or antagonist properties, long acting, and less adverse effects.

Overview on telmisartan therapy

“…Moreover, Telmisartan treatment can diminish the levels of interleukins and TNFα and thereby decrease the incidence of atherosclerosis and stenosis [15,16]. The effect of Telmisartan on renal system manifested by decreasing microalbuminuria, oxidative stress and inflammation and achieved by activation of angiotensin II type 2 receptor and augmentation of superoxide dismutase enzyme .This features can lead to lower the incidence of proteinuria and nephropathy and ameliorate the function of renal endothelium [17].…”