Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis

Fantus, Richard J.; Lin, Jasmine S.; Chang, Cecilia; Pham, Minh; Dubin, Justin M.; Brannigan, Robert E.; Halpern, Joshua A.

doi:10.1016/j.urology.2023.01.015

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…Alterations in sex hormone levels may also be another mechanism involved in the adverse association of poorer SRH with semen quality . Primates exposed to acute and chronic social stresses have been found to alter the reproductive axis and give rise to suppression of the secretion of reproductive hormones, leading to lower semen quality . As mentioned previously, epidemiological studies have found associations between SRH and altered circulating reproductive hormones …”

Section: Discussionmentioning

confidence: 83%

“…68,69 Primates exposed to acute and chronic social stresses have been found to alter the reproductive axis and give rise to suppression of the secretion of reproductive hormones, 70 leading to lower semen quality. 71,72 As mentioned previously, epidemiological studies have found associations between SRH and altered circulating reproductive hormones. [24][25][26]…”

Section: Jama Network Open | Public Healthmentioning

confidence: 86%

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Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

Liu,

Deng,

Chen

et al. 2024

JAMA Netw Open

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ImportanceNumerous studies have documented the association of self-rated health (SRH) with chronic diseases. However, few studies have investigated its association with semen quality.ObjectiveTo examine the association of SRH with semen quality among men undergoing assisted reproductive technology (ART) in China.Design, Setting, and ParticipantsThis cross-sectional study recruited male partners in couples undergoing ART treatment at the Center for Reproductive Medicine, Tongji Hospital, Wuhan, China. A total of 1262 men underwent 2 semen examinations and completed a questionnaire on SRH between December 2018 and January 2020. Data analysis was performed from November 20, 2022, to March 24, 2023.ExposureSRH, including overall physical and mental health, as well as reproductive-related physical and mental health specifically, were reported at baseline recruitment.Main Outcomes and MeasuresSperm concentration, sperm progressive motility, sperm motility, and sperm count as semen quality parameters.ResultsThe study included 1262 men with a mean (SD) age of 32.79 (5.25) years and body mass index of 24.37 (3.68). Men with poorer SRH had lower semen quality (eg, sperm concentration among poor vs very good overall physical health: percentage variation, −14.67%; 95% CI, −23.62% to −4.66%). Among 4 components of SRH, a greater reduction in semen quality was estimated for reproductive-related SRH compared with overall SRH, whereas the greatest reduction was observed for reproductive-related physical SRH. In comparison with men with very good reproductive-related physical SRH, men with poor reproductive-related physical SRH had differences of −24.78% (95% CI, −32.71% to −15.93%) and −25.61% (95% CI, −33.95% to −16.22%) in sperm count and concentration, respectively, and regression coefficients of −9.38 (95% CI, −12.01 to −6.76) and −9.24 (95% CI, −11.82 to −6.66) for sperm motility and sperm progressive motility, respectively.Conclusions and RelevanceIn this cross-sectional study of Chinese men, poorer SRH was associated with lower semen quality, and reproductive-related physical SRH was the most pronounced indicator. Our findings suggest that SRH, especially reproductive-related physical SRH, was a good indicator of semen quality, which should inform public and clinical regulatory decisions.

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Section: Discussionmentioning

confidence: 83%

Section: Jama Network Open | Public Healthmentioning

confidence: 86%

Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

Liu,

Deng,

Chen

et al. 2024

JAMA Netw Open

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“…19,20 Finally, FSH may be useful in predicting longitudinal deterioration in semen parameters among men with a normal SA at presentation. 21 Our prior study found that elevated FSH was a harbinger of decline in TMSC, and for men presenting with low-normal semen parameters and elevated FSH, cryopreservation of sperm or more expedient progression to intrauterine insemination may be warranted.…”

Section: Discussionmentioning

confidence: 91%

Distribution and Positive Predictive Value of Follicle Stimulating Hormone Among Nonazoospermic Men

Hayon,

Kumar,

Greenberg

et al. 2024

Journal of Urology

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“…For example, elevated FSH in a normozoospermic man may be a harbinger of future decline in semen parameters. 2 For now, there is no serum marker that clearly and reliably reflects male reproductive status. Until we identify novel diagnostics that more accurately reflect male reproductive potential, FSH is here to stay.…”

Section: Reply By Authorsmentioning

confidence: 99%

“…The authors' use of a total motile sperm count (TMSC) cutoff of 20 million to identify normospermia emanates from the report of Hamilton et al 2 Normospermia and fertile are not interchangeable semantically or clinically. The Guzick et al study 3 included semen samples from fertile controls and infertile men.…”

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confidence: 99%

Reply by Authors

Hayon,

Kumar,

Greenberg

et al. 2024

Journal of Urology

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Much has been written about follicle stimulating hormone (FSH) in the oligo-azoospermic, but not in the normospermic, patient. The results of this large retrospective review using FSH as a metric to help differentiate who is fertile 1 raise 2 clinically important questions: who should have an FSH level and who is truly fertile?The goal of the male fertility specialist is to help couples become parents. While improving one's sperm count, motility, and morphology are gratifying, the outcome we all strive for is a baby. In this review the authors are simply looking at moving sperm to define fertility. However, the way we define fertility matters. It is obviously not a simple task.

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Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis

Cited by 7 publications

References 10 publications

Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

Distribution and Positive Predictive Value of Follicle Stimulating Hormone Among Nonazoospermic Men

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