Compensatory adaptation and diversification subsequent to evolutionary rescue in a model adaptive radiation

Zhou, Donghao; Zhang, Quan Guo

doi:10.1002/ece3.7792

Cited by 4 publications

(1 citation statement)

References 68 publications

(103 reference statements)

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“…The observed effect of drug rotation frequency in the present study was consistent with evolutionary rescue and compensatory evolution theories (Figure S1). Evolutionary rescue is not without costs, and the costs include reduction in population sizes and the loss of genetic diversity (Orr & Unckless, 2014; Osmond & Coop, 2020; Zhou & Zhang, 2021), and theory suggests such costs could reduce the potential for further adaptation (Carlson et al, 2014; Wahl & Tanaka, 2022). Fast drug rotation would give little time for the previously rescued populations to compensate for such costs, and thus decreased the chance of future evolutionary rescue under a novel stress.…”

Section: Discussionmentioning

confidence: 99%

Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment

Zhou

Zhang

2023

J of Evolutionary Biology

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Evolutionary rescue is a process by which a population escapes extinction through adaptive evolution under lethal environmental stress, where genotypes responsible for the recovery of population growth may come from standing genetic variation, gene flow or de novo mutations. A notable example of evolutionary rescue is the evolution of drug resistance in pathogens. A number of drug administration strategies have been proposed to limit resistance evolution or to accelerate resistance reversion following drug treatment termination; these include aggressive chemotherapy, drug combination and drug-phage combination (Angst et al., 2021;

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Section: Discussionmentioning

confidence: 99%

Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment

Zhou

Zhang

2023

J of Evolutionary Biology

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The origin of genetic and metabolic systems: Evolutionary structuralinsights

Deng¹

2023

Heliyon

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Clinically relevant mutations in regulatory regions of metabolic genes facilitate early adaptation to ciprofloxacin in Escherichia coli

Pal,

Ghosh,

Thakur

et al. 2024

Nucleic Acids Research

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The genomic landscape associated with early adaptation to ciprofloxacin is poorly understood. Although the interplay between core metabolism and antimicrobial resistance is being increasingly recognized, mutations in metabolic genes and their biological role remain elusive. Here, we exposed Escherichia coli to increasing gradients of ciprofloxacin with intermittent transfer-bottlenecking and identified mutations in three non-canonical targets linked to metabolism including a deletion (tRNA-ArgΔ414-bp) and point mutations in the regulatory regions of argI (ARG box) and narU. Our findings suggest that these mutations modulate arginine and carbohydrate metabolism, facilitate anaerobiosis and increased ATP production during ciprofloxacin stress. Furthermore, mutations in the regulatory regions of argI and narU were detected in over 70% of sequences from clinical E. coli isolates and were overrepresented among ciprofloxacin-resistant isolates. In sum, we have identified clinically relevant mutations in the regulatory regions of metabolic genes as a central theme that drives physiological changes necessary for adaptation to ciprofloxacin stress.

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Compensatory adaptation and diversification subsequent to evolutionary rescue in a model adaptive radiation

Abstract: Environmental changes have threatened the persistence of many local biological populations and also caused a decline of biodiversity on the global scale. Processes that may promote population survival in degraded habitats have been studied extensively, among which is evolutionary rescue (

Cited by 4 publications

References 68 publications

Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment

Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment

The origin of genetic and metabolic systems: Evolutionary structuralinsights

Clinically relevant mutations in regulatory regions of metabolic genes facilitate early adaptation to ciprofloxacin in Escherichia coli

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