Compensatory articulatory mechanisms preserve intelligibility in prodromal Parkinson's disease

Thies, Tabea; Mücke, Doris; Geerts, Nuria; Seger, Aline; Fink, Gereon R.; Barbe, Michael T.; Sommerauer, Michael

doi:10.1016/j.parkreldis.2023.105487

Parkinsonism & Related Disorders

2023

DOI: 10.1016/j.parkreldis.2023.105487

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Compensatory articulatory mechanisms preserve intelligibility in prodromal Parkinson's disease

Tabea Thies

Doris Mücke

Nuria Geerts

et al.

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2024

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Cited by 4 publications

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Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

Illner,

Novotný,

Kouba

et al. 2024

Movement Disorders

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BackgroundSpeech dysfunction represents one of the initial motor manifestations to develop in Parkinson's disease (PD) and is measurable through smartphone.ObjectiveThe aim was to develop a fully automated and noise‐resistant smartphone‐based system that can unobtrusively screen for prodromal parkinsonian speech disorder in subjects with isolated rapid eye movement sleep behavior disorder (iRBD) in a real‐world scenario.MethodsThis cross‐sectional study assessed regular, everyday voice call data from individuals with iRBD compared to early PD patients and healthy controls via a developed smartphone application. The participants also performed an active, regular reading of a short passage on their smartphone. Smartphone data were continuously collected for up to 3 months after the standard in‐person assessments at the clinic.ResultsA total of 3525 calls that led to 5990 minutes of preprocessed speech were extracted from 72 participants, comprising 21 iRBD patients, 26 PD patients, and 25 controls. With a high area under the curve of 0.85 between iRBD patients and controls, the combination of passive and active smartphone data provided a comparable or even more sensitive evaluation than laboratory examination using a high‐quality microphone. The most sensitive features to induce prodromal neurodegeneration in iRBD included imprecise vowel articulation during phone calls (P = 0.03) and monopitch in reading (P = 0.05). Eighteen minutes of speech corresponding to approximately nine calls was sufficient to obtain the best sensitivity for the screening.ConclusionWe consider the developed tool widely applicable to deep longitudinal digital phenotyping data with future applications in neuroprotective trials, deep brain stimulation optimization, neuropsychiatry, speech therapy, population screening, and beyond. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

Illner,

Novotný,

Kouba

et al. 2024

Movement Disorders

View full text Add to dashboard Cite

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From prodromal stages to clinical trials: The promise of digital speech biomarkers in Parkinson's disease

Rusz,

Krack,

Tripoliti

2024

Neuroscience & Biobehavioral Reviews

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Unveiling early signs of Parkinson’s disease via a longitudinal analysis of celebrity speech recordings

Favaro,

Butala,

Thebaud

et al. 2024

npj Parkinsons Dis.

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Numerous studies proposed methods to detect Parkinson’s disease (PD) via speech analysis. However, existing corpora often lack prodromal recordings, have small sample sizes, and lack longitudinal data. Speech samples from celebrities who publicly disclosed their PD diagnosis provide longitudinal data, allowing the creation of a new corpus, ParkCeleb . We collected videos from 40 subjects with PD and 40 controls and analyzed evolving speech features from 10 years before to 20 years after diagnosis. Our longitudinal analysis, focused on 15 subjects with PD and 15 controls, revealed features like pitch variability, pause duration, speech rate, and syllable duration, indicating PD progression. Early dysarthria patterns were detectable in the prodromal phase, with the best classifiers achieving AUCs of 0.72 and 0.75 for data collected ten and five years before diagnosis, respectively, and 0.93 post-diagnosis. This study highlights the potential for early detection methods, aiding treatment response identification and screening in clinical trials.

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Compensatory articulatory mechanisms preserve intelligibility in prodromal Parkinson's disease

Cited by 4 publications

References 24 publications

Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

From prodromal stages to clinical trials: The promise of digital speech biomarkers in Parkinson's disease

Unveiling early signs of Parkinson’s disease via a longitudinal analysis of celebrity speech recordings

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