Compensatory hypertrophy of the teres minor muscle after large rotator cuff tear model in adult male rat

Ichinose, Tsuyoshi; Yamamoto, Atsushi; Kobayashi, Tsutomu; Shitara, Hitoshi; Shimoyama, Daisuke; Iizuka, Haku; Koibuchi, Noriyuki; Takagishi, Kenji

doi:10.1016/j.jse.2015.07.023

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Spontaneous reattachment of the supraspinatus tendon is associated with recovery of muscle mass and collagen content [ 4 , 77 ]. Efforts to avoid reattachment include removing the distal fragment of tendon [ 30 , 43 ] or using a membrane [ 18 , 24 ] to prevent spontaneous reattachment, while other studies make no mention of these deterrents [ 23 , 24 , 35 – 37 ]. We initially tried using membrane and even a polymer gel (not shown) after tenotomy to prevent spontaneous tendon reattachment.…”

Section: Discussionmentioning

confidence: 99%

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear

Valencia

Iyer

Spangenburg

et al. 2017

BMC Musculoskelet Disord

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BackgroundRotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle.MethodsUnilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Maximal tetanic force and susceptibility to injury of the supraspinatus muscle were measured in vivo at day 2 and day 15 after tenotomy. Supraspinatus muscles were weighed and harvested for histologic analysis of the neuromuscular junction (NMJ), intramuscular lipid, and collagen.ResultsTenotomy resulted in eventual atrophy and weakness. Despite no loss in muscle mass at day 2 there was a 30% reduction in contractile force, and a decrease in NMJ continuity and size. Reduced force persisted at day 15, a time point when muscle atrophy was evident but NMJ morphology was restored. At day 15, torn muscles had decreased collagen-packing density and were also more susceptible to contraction-induced injury.ConclusionMuscle size and histopathology are not direct indicators of overall RTC contractile health. Changes in NMJ morphology and collagen organization were associated with changes in contractile function and thus may play a role in response to injury. Although our findings are limited to the acute phase after a RTC tear, the most salient finding is that RTC tenotomy results in increased susceptibility to injury of the supraspinatus.

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Section: Discussionmentioning

confidence: 99%

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear

Valencia

Iyer

Spangenburg

et al. 2017

BMC Musculoskelet Disord

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“…It has been demonstrated that the loss of proportion between the muscles of the RCTFC occurs in massive tears, where the vectors of force change, altering the characteristics of the muscle, such as the force and muscle volume [6,10]. Piepers et al [17] evaluated 27 shoulders by segmentation, finding that the correlation between the anterior and posterior muscles of the RCTFC in non-pathological shoulders was strong (Spearman's q: p = 0.83), finding no significant differences between the two muscle units.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies in animal models have associated the compensatory hypertrophy that is presented in the teres minor muscle following massive tears of the subscapularis muscle [10] with the consequent proportional loss of balance and function between the two muscle units, which can be estimated based on the muscle volume.…”

Section: Introductionmentioning

confidence: 99%

An age- and gender-related three-dimensional analysis of rotator cuff transverse force couple volume ratio in 304 shoulders

Espinosa-Uribe

Negreros-Osuna

et al. 2016

Surg Radiol Anat

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“…Remarkably, metaplasia in the tendon is associated with the mTOR signaling pathway. The mTOR signaling pathway was activated and mediated fatty infiltration and muscle atrophy after rotator cuff transection and denervation in rats [ 47 , 48 , 49 ]. Moreover, mechanical overloading also induced activation of mTOR signaling that increased the proliferation and expression of non-tenocyte markers in TDSCs [ 50 ].…”

Section: Clinical and Pre-clinical Evidence Of Potential Sources And ...mentioning

confidence: 99%

Roles of Oxidative Stress in Acute Tendon Injury and Degenerative Tendinopathy—A Target for Intervention

Lui

Zhang

Yao

et al. 2022

IJMS

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Both acute and chronic tendon injuries are disabling sports medicine problems with no effective treatment at present. Sustained oxidative stress has been suggested as the major factor contributing to fibrosis and adhesion after acute tendon injury as well as pathological changes of degenerative tendinopathy. Numerous in vitro and in vivo studies have shown that the inhibition of oxidative stress can promote the tenogenic differentiation of tendon stem/progenitor cells, reduce tissue fibrosis and augment tendon repair. This review aims to systematically review the literature and summarize the clinical and pre-clinical evidence about the potential relationship of oxidative stress and tendon disorders. The literature in PubMed was searched using appropriate keywords. A total of 81 original pre-clinical and clinical articles directly related to the effects of oxidative stress and the activators or inhibitors of oxidative stress on the tendon were reviewed and included in this review article. The potential sources and mechanisms of oxidative stress in these debilitating tendon disorders is summarized. The anti-oxidative therapies that have been examined in the clinical and pre-clinical settings to reduce tendon fibrosis and adhesion or promote healing in tendinopathy are reviewed. The future research direction is also discussed.

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Compensatory hypertrophy of the teres minor muscle after large rotator cuff tear model in adult male rat

Cited by 9 publications

References 29 publications

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear

An age- and gender-related three-dimensional analysis of rotator cuff transverse force couple volume ratio in 304 shoulders

Roles of Oxidative Stress in Acute Tendon Injury and Degenerative Tendinopathy—A Target for Intervention

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