Compensatory Neural Responses to Cognitive Fatigue in Young and Older Adults

Samuel, Immanuel Babu Henry; Wang, Chao; Burke, Sarah; Kluger, Benzi M.; Ding, Mingzhou

doi:10.3389/fncir.2019.00012

Cited by 14 publications

(8 citation statements)

References 53 publications

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“…Haubert and colleagues (2018) observed an increase of N1 amplitudes with time-on-task in individuals performing in a visual attention task. Samuel et al (2019), moreover, found early ERP components to decrease over time, but late ERP components at frontal recording sites to increase. Similarly, Wang et al (2016) observed increases of late ERP amplitudes (640-1,272 ms) at frontal leads during the first 80 min of a 160-min Stroop task experiment.…”

Section: Discussionmentioning

confidence: 91%

Inverse effects of time‐on‐task in task‐related and task‐unrelated theta activity

Arnau

Brümmer²,

Liegel

et al. 2021

Psychophysiology

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Human behavior is not stable over time. A decline of performance with increasing time-on-task is a common observation in everyday life. This phenomenon is referred to as mental fatigue. It is a cognitive state which is characterized by a reduced alertness, deteriorated performance (Borghini et al., 2014;Grandjean, 1979), and an aversion to invest further effort into a task (Hockey, 1997). The occurrence of mental fatigue has been found to be more likely in rather monotonous and repetitive tasks (Körber et al., 2015;Thiffault & Bergeron, 2003), as well as in in partially automated tasks (Körber et al., 2015;Saxby et al., 2008). This observation renders working environments in which monitoring tasks are

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Section: Discussionmentioning

confidence: 91%

Inverse effects of time‐on‐task in task‐related and task‐unrelated theta activity

Arnau

Brümmer²,

Liegel

et al. 2021

Psychophysiology

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“…Aged individuals in comparison to younger adults exhibited a stronger suppressive effect of surround, showing high-contrast suppression when both the center and surround were exposed to the same eye, whereas no such effect was observed when the center and surround were exposed to separate eyes independently [3,93,94]. Hence, it seems that there is a generalized contextual change in surround suppression, contrast, and orientation with normal aging that does not result in a significant decline of performance in aged adults [95]. Even though visual processing is more susceptible to the effects of aging, neural changes in visual circuits related to cognitive tasks do not show a major performance decline in aged individuals as compared to young adults, despite age-related impairment in neural responses of older subjects.…”

Section: Dynamic Balance Of Neuronal Response Properties In Young Andmentioning

confidence: 90%

Differential Circuit Mechanisms of Young and Aged Visual Cortex in the Mammalian Brain

Mohammed¹

2021

NeuroSci

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The main goal of this review is to summarize and discuss (1) age-dependent structural reorganization of mammalian visual cortical circuits underlying complex visual behavior functions in primary visual cortex (V1) and multiple extrastriate visual areas, and (2) current evidence supporting the notion of compensatory mechanisms in aged visual circuits as well as the use of rehabilitative therapy for the recovery of neural plasticity in normal and diseased aging visual circuit mechanisms in different species. It is well known that aging significantly modulates both the structural and physiological properties of visual cortical neurons in V1 and other visual cortical areas in various species. Compensatory aged neural mechanisms correlate with the complexity of visual functions; however, they do not always result in major circuit alterations resulting in age-dependent decline in performance of a visual task or neurodegenerative disorders. Computational load and neural processing gradually increase with age, and the complexity of compensatory mechanisms correlates with the intricacy of higher form visual perceptions that are more evident in higher-order visual areas. It is particularly interesting to note that the visual perceptual processing of certain visual behavior functions does not change with age. This review aims to comprehensively discuss the effect of normal aging on neuroanatomical alterations that underlie critical visual functions and more importantly to highlight differences between compensatory mechanisms in aged neural circuits and neural processes related to visual disorders. This type of approach will further enhance our understanding of inter-areal and cortico-cortical connectivity of visual circuits in normal aging and identify major circuit alterations that occur in different visual deficits, thus facilitating the design and evaluation of potential rehabilitation therapies as well as the assessment of the extent of their rejuvenation.

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“…These brain regions mainly subserve cognitive domains such as attention, executive functions, visuospatial functions, episodic memory, language, and number processing [ 80 – 83 ]. The increased Rs-FC in the dorsal attention RSN could be a compensatory attempt [ 56 ] to preserve these cognitive functions and thus maintain attentional resources in the presence of cognitive fatigue [ 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States

Bharti

Graham²,

Benatar³

et al. 2022

PLoS ONE

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Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive degeneration of upper motor neurons and lower motor neurons, and frontotemporal regions resulting in impaired bulbar, limb, and cognitive function. Magnetic resonance imaging studies have reported cortical and subcortical brain involvement in the pathophysiology of ALS. The present study investigates the functional integrity of resting-state networks (RSNs) and their importance in ALS. Intra- and inter-network resting-state functional connectivity (Rs-FC) was examined using an independent component analysis approach in a large multi-center cohort. A total of 235 subjects (120 ALS patients; 115 healthy controls (HC) were recruited across North America through the Canadian ALS Neuroimaging Consortium (CALSNIC). Intra-network and inter-network Rs-FC was evaluated by the FSL-MELODIC and FSLNets software packages. As compared to HC, ALS patients displayed higher intra-network Rs-FC in the sensorimotor, default mode, right and left fronto-parietal, and orbitofrontal RSNs, and in previously undescribed networks including auditory, dorsal attention, basal ganglia, medial temporal, ventral streams, and cerebellum which negatively correlated with disease severity. Furthermore, ALS patients displayed higher inter-network Rs-FC between the orbitofrontal and basal ganglia RSNs which negatively correlated with cognitive impairment. In summary, in ALS there is an increase in intra- and inter-network functional connectivity of RSNs underpinning both motor and cognitive impairment. Moreover, the large multi-center CALSNIC dataset permitted the exploration of RSNs in unprecedented detail, revealing previously undescribed network involvement in ALS.

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Compensatory Neural Responses to Cognitive Fatigue in Young and Older Adults

Cited by 14 publications

References 53 publications

Inverse effects of time‐on‐task in task‐related and task‐unrelated theta activity

Inverse effects of time‐on‐task in task‐related and task‐unrelated theta activity

Differential Circuit Mechanisms of Young and Aged Visual Cortex in the Mammalian Brain

Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States

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