Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson’s disease

Stemick, Judith; Gauer, Carina; Wihan, Jeanette; Moceri, Sandra; Xiang, Wei; Hörsten, Stephan von; Kohl, Zacharias; Winkler, Jürgen

doi:10.1016/j.brainres.2020.147119

Cited by 6 publications

(1 citation statement)

References 58 publications

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“…This plugin extracts the skeleton of a binary image, which is further analyzed using the "Analyze Skeleton (2D/3D)" plugin. The branch length of objects .2 mm was summarized to determine the total branch length in each image (Stemick et al, 2020).…”

Section: Image Acquisition and Analysismentioning

confidence: 99%

CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy

et al. 2022

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Significance StatementMyeloid cells have been implicated as detrimental in the disease pathogenesis of multiple system atrophy. However, longterm CSF1R-dependent depletion of these cells in a mouse model of multiple system atrophy demonstrates a two-faced effect involving an improved survival associated with a delayed onset of disease and reduced inflammation which was contrasted by severely impaired motor functions, synaptic signaling, and neuronal circuitries. Thus, this study unraveled a complex role of myeloid cells in multiple system atrophy, which indicates important functions beyond the previously described disease-associated, destructive phenotype and emphasized the need of further investigation to carefully and individually fine-tune immunologic processes in different neurodegenerative diseases.

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Section: Image Acquisition and Analysismentioning

confidence: 99%