Comperative Study on Anesthetic Effect of Xylazine-Ketamine And Diazepam-Ketamine In Rabbit Model

Abstract

This study was conducted to investigate the anesthetic effects of Xylazine-ketamine and Diazepam-ketamine in rabbits. Twelve adult white New-Zealand rabbits weighing 1.3+0.2 kg, were divided into two groups. A (Xylazine 5mg/kg – ketamine 35mg/kg) and B (Diazepam 5mg/kg – ketamine 35mg/kg). However, the following parameters were observed: analgesic effects (onset and duration) and clinical-parameters (means of heart-rates/BPM, respiratory-rates/BPM and rectal temperature. The onset was significantly p<0.05 increased, and the duration was significantly p>0.05 decreased in A. The heart-rate and the respiratory-rate was significantly p<0.01 decreased in A. But the rectal temperature decreased non-significantly p>0.05 in both groups. General observations: in Group A, urination, nasal-discharge, salivation and lacrimation were present, in Group B, defecation, corneal-reflex and pedal-reflex were observed at their peak. It was concluded that the xylazine-ketamine is used for clinical/surgical procedures, while diazepam-ketamine may further be investigated by using other analgesics with this combination.