A student-directed approach to interprofessional learning (IPL) can overcome difficulties such as incompatible timetables, limited staff resources and crowded disciplinary curricula. However, it is unclear whether such approaches to IPL can produce quality student learning, including attitudinal change. This study aimed to investigate the influence of a student-directed experiential IPL activity on attitudes towards interprofessional learning and working. A single group, pre/post-test design was used. Participants from medicine, nursing, exercise physiology, diagnostic radiography, occupational therapy, pharmacy, physiotherapy, and speech pathology disciplines completed three validated questionnaires (Revised Readiness for Interprofessional Learning Scale (RIPLS); Modified Interdisciplinary Education Perception Scale (IEPS); and Interprofessional Relationships Scale (IRS)) before and after a five week studentdirected interprofessional learning activity. Students were also surveyed on frequency of social media usage and mode of communication with team members during the IPL activity. Seventy-seven students participated in the IPL activity. There were significant increases in the modified IEPS and IRS scores before and after the IPL activity but not the RIPLS. Social media and face-to-face meetings were used equally by students to communicate with team members during the IPL activity. The overall results support the effectiveness of a student-directed experiential IPL activity to significantly influence attitudes towards interprofessional learning and working. This approach may offer a viable means of overcoming the curricular challenges faced when implementing IPL on a large scale. The role of social media in facilitating collaborative learning warrants further exploration.