In the framework of lifelong learning, it is not only important to identify the teachers key competences and the training to develop them, but also that teachers take ownership of the development of their competences. Since the European Council meeting on 23-24 March 2000 in Lisbon, higher education institutions have made considerable efforts to implement a competence-based approach, even though they vary greatly not only between countries, but also between institutions within the same country. These differences highlight the need for a more global model of competence framework for teachers, aligning initial training, ongoing training and the professional development of them. In this contribution, the steps followed in the process to design, validate and apply the global framework of teachers' key competences are presented. The aim is to ensure the transferability of this framework to other contexts and to promote global harmonization, to encourage its use in future studies and research.