PurposeThe design for deconstruction (DfD) technique, a contemporaneous solution to demolition by optimizing disassembly activities to enable reuse, has recently emerged with several promises to promote the circular economy. However, little attention has been given to its implementation among design professionals, especially in the Global South. Therefore, this study aims to explore the drivers for DfD implementation among design professionals in the Ghanaian construction industry (GCI).Design/methodology/approachThe study adopted a mixed research approach (explanatory sequential design) with an initial quantitative instrument phase, followed by a qualitative data collection phase. Data from the survey were analyzed using mean, standard deviation, one-sample t-Test, and normalization value (NV) test after a review of pertinent literature. These data were then validated through semistructured interviews with ten design professionals with in-depth knowledge of DfD.FindingsThe findings revealed that although all ten drivers are important, the eight key drivers for the DfD implementation were identified as, in order of importance, “Availability of computer software applications regarding DfD,” “Inclusion of DfD in the formal education of design professionals,” “Increasing public awareness of the concept of DfD,” “Organizing workshops/seminars for design professionals on the concept of DfD,” “Availability of DfD training,” “Regulation regarding DfD,” “Industry guidance regarding DfD” and “Establishing a market for salvaged construction components.”Originality/valueThis study's findings provide insights into an under-investigated topic in Ghana and offer new and additional information and insights into the current state-of-the-art on the factors that drive DfD implementation.