2012
DOI: 10.3892/etm.2012.494
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Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy

Abstract: Abstract. Radiation with or without chemotherapy is considered the mainstay of treatment for the majority of patients with oropharyngeal cancer. The goal of this study was to analyze competing causes of mortality in patients with oropharyngeal cancer with long-term follow-up. We queried the Surveillance, Epidemiology and End Results (SEER) database and identified 3728 patients with oropharyngeal cancer treated between 1988 and 2001 with definitive radiotherapy. We analyzed predictors of overall survival and ri… Show more

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Cited by 4 publications
(4 citation statements)
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“…Finally, 19.48% of the observed deaths were not attributable to OPSCC, which is consistent with internationally published data and reflects the high burden of comorbidities present in the group of patients with OPSCC. Kao et al [34] analysed the competing causes of death in patients with oropharyngeal cancer in a North American population representative of the period prior to the epidemiologic transition (1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001), showing that in 36% of the cases the cause of mortality was not related to OPSCC [34]. This higher proportion, with respect to that observed in our study, may be related to the epidemiological differences between the two populations, the INCC population being representative of the post-epidemiological transition period and therefore including patients with fewer classical risk factors such as tobacco and alcohol, both habits associated with the development of other neoplasms and cardiovascular diseases [35,36].…”
Section: Discussionmentioning
confidence: 99%
“…Finally, 19.48% of the observed deaths were not attributable to OPSCC, which is consistent with internationally published data and reflects the high burden of comorbidities present in the group of patients with OPSCC. Kao et al [34] analysed the competing causes of death in patients with oropharyngeal cancer in a North American population representative of the period prior to the epidemiologic transition (1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001), showing that in 36% of the cases the cause of mortality was not related to OPSCC [34]. This higher proportion, with respect to that observed in our study, may be related to the epidemiological differences between the two populations, the INCC population being representative of the post-epidemiological transition period and therefore including patients with fewer classical risk factors such as tobacco and alcohol, both habits associated with the development of other neoplasms and cardiovascular diseases [35,36].…”
Section: Discussionmentioning
confidence: 99%
“…Traditional open surgical treatment, including mandibular incision and pharyngectomy, is likely to cause serious complications, such as speech, swallowing, and breathing disorders ( 10 ). Recently, as a relatively safe, effective, and minimally invasive treatment, transoral robotic surgery has been increasingly used in the treatment of TSCC ( 11 ), and the results are comparable to those of open surgery ( 12 ).…”
Section: Introductionmentioning
confidence: 99%
“…For most patients with TSCC, the improvement in survival means an increased risk of other diseases, including second primary malignancies (SPMs) and cardiovascular diseases ( 11 ). SPMs are the second leading cause of death in patients with oropharyngeal cancer, contributing to 69% of deaths in TSCC patients after 3 years of TSCC diagnosis ( 12 ). Although the pathogenesis of SPMs in TSCC is unclear, the patients experience a shortened survival period upon disease occurrence, and adolescents and young adults with SPMs have a worse survival outcome than those with only primary cancer ( 14 ).…”
Section: Introductionmentioning
confidence: 99%
“…Although the improved survival of patients with HPV‐positive tumors is well demonstrated, little is known about the actual causes of death. A recent study comprising 4245 deaths in 5905 patients treated for OPSCC reported that the most common cause of death after the primary malignancy was cardiopulmonary diseases followed by secondary malignancies , but the timing and HPV status were not reported. In contrast, another study failed to show an increased risk of death due to cardiovascular disease or secondary malignancies in oropharyngeal cancer patients .…”
Section: Introductionmentioning
confidence: 99%