2020
DOI: 10.1021/jasms.0c00344
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Competing Deprotonation and Electron Capture Dissociation in MALDI Mass Spectrometry

Abstract: A protonation/deprotonation mechanism has been established for the interpretation of ions in MALDI. We show herein that negative ions can be generated in different ways. Molecules with different electron affinities have been spotted on surfaces of TiO 2 , ZnO, and a stainless steel plate for the investigation of electron capture dissociation in comparison with photo-or thermal-induced deprotonation upon irradiation of the third harmonic of Nd 3+ :YAG (355 nm) laser pulses. Detection of C60 •− and Fe (II) (porp… Show more

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Cited by 2 publications
(2 citation statements)
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“…Yin, Li et al characterized how high pressure in the source can supercharge native-like intact protein complexes in nanoelectrospray . Zhong et al studied the mechanism for the formation of negative ions during the matrix assisted laser desorption ionization (MALDI) process . Xiao, Guo et al used α-cyano-4-hydroxycinnamic acid as a reactive matrix for analysis of glutathione using MALDI MS, and the sensitivity was improved to 200 pmol/μL as the limit of detection …”
Section: Instrumentationmentioning
confidence: 99%
“…Yin, Li et al characterized how high pressure in the source can supercharge native-like intact protein complexes in nanoelectrospray . Zhong et al studied the mechanism for the formation of negative ions during the matrix assisted laser desorption ionization (MALDI) process . Xiao, Guo et al used α-cyano-4-hydroxycinnamic acid as a reactive matrix for analysis of glutathione using MALDI MS, and the sensitivity was improved to 200 pmol/μL as the limit of detection …”
Section: Instrumentationmentioning
confidence: 99%
“…As reported previously, in the ionization step, excited electrons in nanostructures are main subjects which are produced by the laser energy. 29 By transferring these electrons to the analytes, neutral molecules can be changed into ions. Thus, the electron transfer mechanism is operative in the ionization process.…”
Section: Ionization Efficiency Of the Psi And Tsi Substratesmentioning
confidence: 99%