Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease

Rafiq, Muhammad; Dandare, Abdullahi; Javed, Arham; Liaquat, Afrose; Raja, Afraz Ahmad; Awan, Hassaan Mehboob; Khan, Muhammad Jadoon; Naeem, Ayesha

doi:10.3390/genes14030550

Cited by 10 publications

(3 citation statements)

References 85 publications

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“…Four sets of experiments on CKD gene expression profiling by array were identified, namely GSE37171 [ 27 ], GSE43484 [ 28 ], GSE66494 [ 29 ] and GSE142153 [ 30 ] ( Supplementary Table S2 ). The methodology followed for the analysis is already reported in detail [ 31 , 32 , 33 , 34 ]. Briefly, unprocessed data of these experiments were acquired from Gene Expression Omnibus (GEO) of NCBI, and analyzed using GEO2R to find differentially expressed genes (DEGs) and the level of their expression.…”

Section: Methodsmentioning

confidence: 99%

Computational Analysis Reveals Distinctive Interaction of miRNAs with Target Genes in the Pathogenesis of Chronic Kidney Disease

Salim

Dandare

Khalil

et al. 2023

Genes

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The regulation of genes is crucial for maintaining a healthy intracellular environment, and any dysregulation of gene expression leads to several pathological complications. It is known that many diseases, including kidney diseases, are regulated by miRNAs. However, the data on the use of miRNAs as biomarkers for the diagnosis and treatment of chronic kidney disease (CKD) are not conclusive. The purpose of this study was to elucidate the potential of miRNAs as an efficient biomarker for the detection and treatment of CKD at its early stages. Gene expression profiling data were acquired from the Gene Expression Omnibus (GEO) and differentially expressed genes (DEGs) were identified. miRNAs directly associated with CKD were obtained from an extensive literature search. Network illustration of miRNAs and their projected target differentially expressed genes (tDEGs) was accomplished, followed by functional enrichment analysis. hsa-miR-1-3p, hsa-miR-206, hsa-miR-494 and hsa-miR-577 exhibited a strong association with CKD through the regulation of genes involved in signal transduction, cell proliferation, the regulation of transcription and apoptotic process. All these miRNAs have shown significant contributions to the inflammatory response and the processes which eventually lead to the pathogenesis of CKD. The in silico approach used in this research represents a comprehensive analysis of identified miRNAs and their target genes for the identification of molecular markers of disease processes. The outcomes of the study recommend further efforts for developing miRNA biomarkers set for the early diagnosis of CKD.

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Section: Methodsmentioning

confidence: 99%

Computational Analysis Reveals Distinctive Interaction of miRNAs with Target Genes in the Pathogenesis of Chronic Kidney Disease

Salim

Dandare

Khalil

et al. 2023

Genes

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“…Данная микроРНК произошла от LINE2 [52]. MiR-495 (источник -ERVL [52]) участвует в патогенезе АС путем связывания с кольцевой РНК hsa_circ_0126672 [53]. MiR-520d (произошла от SINE/Alu [23]) ингибирует экспрессию гена PCSK9 (пропротеинконвертаза субтилизин/кексин типа 9, мутации в котором вызывают семейную гиперхолестеринемию), вызывающего деградацию рецепторов липопротеинов низкой плотности [54].…”

Section: роль произошедших от ретроэлементов микрорнк в развитии атер...unclassified

Role of MicroRNAs and Retroelements in the Pathogenesis of Atherosclerosis

Mustafin,

Galieva

2024

Arhivʺ vnutrennej mediciny

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Atherosclerosis is the leading cause of cardiovascular disease among adults. The incidence of atherosclerosis increases significantly with age, which indicates the possible influence of aging mechanisms on the development of the disease, including changes in epigenetic factors caused by pathological activation of transposable elements. Triggers of atherosclerosis are also viral infections, which promote the expression of retroelements that stimulate the interferon response with the development of chronic inflammation. Activated retroelements also alter the regulation of immune system genes and epigenetic factors, including the pathological production of microRNAs and long non-coding RNAs. A promising direction for atherosclerosis treatment is the epigenetic impact on the expression of specific genes involved in the pathogenesis of atherosclerosis using small interfering RNAs. In this regard, the drugs inclisiran and olpasiran have undergone clinical trials and have shown their effectiveness. Therefore, it is important to search for new molecular targets in this direction, which can serve as transposons, which are sources of non-coding RNAs. Changes in the activity of retroelements during aging have a global regulatory effect on the functioning of the entire genome, contributing to the development of age-associated pathology. An analysis of the scientific literature made it possible to identify 29 microRNAs derived from retroelements, changes in the expression of which have been identified both during aging and atherosclerosis. These microRNAs can be used as tools for prolonging life and treating cardiovascular pathology. The results obtained also indicate that retroelements pathologically activated during aging cause the development of atherosclerosis.

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“…Frontiers in Cell and Developmental Biology frontiersin.org artery disease. This circRNA can competitively adsorb numerous miRNAs, including miR-145-5p, and is closely associated with AS (Rafiq et al, 2023). Feng Zhang et al prepared AS rabbit models using a high-fat diet, screened the differentially expressed circRNAs, miRNAs, and mRNAs by RNA-seq and mapped the ceRNA network, concluding that seven circRNAs, including ocu-cirRnovel-18038, were associated with AS by gene function enrichment analysis (Zhang et al, 2018).…”

Section: Figurementioning

confidence: 99%

Non-coding RNAs are key players and promising therapeutic targets in atherosclerosis

Yu,

Yin,

Tang

et al. 2023

Front. Cell Dev. Biol.

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Cardiovascular disease (CVD) is the primary cause of death in humans. Atherosclerosis (AS) is the most common CVD and a major cause of many CVD-related fatalities. AS has numerous risk factors and complex pathogenesis, and while it has long been a research focus, most mechanisms underlying its progression remain unknown. Noncoding RNAs (ncRNAs) represent an important focus in epigenetics studies and are critical biological regulators that form a complex network of gene regulation. Abnormal ncRNA expression disrupts the normal function of tissues or cells, leading to disease development. A large body of evidence suggests that ncRNAs are involved in all stages of atherosclerosis, from initiation to progression, and that some are significantly differentially expressed during AS development, suggesting that they may be powerful markers for screening AS or potential treatment targets. Here, we review the role of ncRNAs in AS development and recent developments in the use of ncRNAs for AS-targeted therapy, providing evidence for ncRNAs as diagnostic markers and therapeutic targets.

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Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease

Cited by 10 publications

References 85 publications

Computational Analysis Reveals Distinctive Interaction of miRNAs with Target Genes in the Pathogenesis of Chronic Kidney Disease

Computational Analysis Reveals Distinctive Interaction of miRNAs with Target Genes in the Pathogenesis of Chronic Kidney Disease

Role of MicroRNAs and Retroelements in the Pathogenesis of Atherosclerosis

Non-coding RNAs are key players and promising therapeutic targets in atherosclerosis

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