2023
DOI: 10.3389/fnins.2023.1195840
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Competing endogenous RNAs in human astrocytes: crosstalk and interacting networks in response to lipotoxicity

Natalia Gil-Jaramillo,
Andrés Felipe Aristizábal-Pachón,
María Alejandra Luque Aleman
et al.

Abstract: Neurodegenerative diseases (NDs) are characterized by a progressive deterioration of neuronal function, leading to motor and cognitive damage in patients. Astrocytes are essential for maintaining brain homeostasis, and their functional impairment is increasingly recognized as central to the etiology of various NDs. Such impairment can be induced by toxic insults with palmitic acid (PA), a common fatty acid, that disrupts autophagy, increases reactive oxygen species, and triggers inflammation. Although the effe… Show more

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“…With the evolving recognition of ceRNA networks in various diseases, research targeting ceRNAs rather than ncRNAs alone may become increasingly important ( Gil-Jaramillo et al, 2023 ). Therefore, GO annotation and KEGG analysis were employed to investigate the functions of differentially expressed circRNAs.…”
Section: Discussionmentioning
confidence: 99%
“…With the evolving recognition of ceRNA networks in various diseases, research targeting ceRNAs rather than ncRNAs alone may become increasingly important ( Gil-Jaramillo et al, 2023 ). Therefore, GO annotation and KEGG analysis were employed to investigate the functions of differentially expressed circRNAs.…”
Section: Discussionmentioning
confidence: 99%