We investigate the dynamics of pairs of drops in microfluidic ladder networks with slanted bypasses, which break the fore-aft structural symmetry. Our analytical results indicate that unlike symmetric ladder networks, structural asymmetry introduced by a single slanted bypass can be used to modulate the relative drop spacing, enabling them to contract, synchronize, expand, or even flip at the ladder exit. Our experiments confirm all these behaviors predicted by theory. Numerical analysis further shows that while ladder networks containing several identical bypasses are limited to nearly linear transformation of input delay between drops, combination of forward and backward slant bypasses can cause significant non-linear transformation enabling coding and decoding of input delays.Understanding the spatiotemporal dynamics of confined immiscible plugs in interconnected fluidic paths is essential for applications ranging from lab-on-chip technologies 1,2 to physiological flows 3 to porous media flows 4 . The traffic of drops or bubbles in even simple networks such as bifurcating channels can be astonishingly complex due to collective hydrodynamic resistive interactions in the branches [5][6][7] . Although such intricate dynamics, in the case of lab-on-chip applications, make device design challenging, the collective behaviors can be harnessed to perform useful tasks such as droplet sorting 8 and storage 9,10 . Recently, the collective dynamics between pairs of drops have been harnessed in the so-called microfluidic ladder networks (MLNs) to control their relative drop spacing 11 . In MLNs, two droplet-carrying parallel channels are connected by narrow bypass channels through which the motion of drops is forbidden but the carrier fluid can leak. Current versions of ladders have fore-aft structural symmetry due to equally-spaced vertical bypasses. Such symmetric ladders are limited in functionality because the distance between pairs of drops have been shown to decrease at the exit only for constant inlet flow [11][12][13] . Since flexible manipulation of drop spacing in networks is crucial for passively regulating a variety of tasks including drop coalescence 14 , detection and storage, there is a need to design microfluidic ladders with multiple functionalities.From a fundamental perspective, the dynamics of drops in MLNs is distinct compared to the widely-studied microfluidic loops 5,7,13,15 . In loops, drops at junctions choose a given branch. These discrete choices make such systems non-linear, enabling coding and decoding of input signals. Since drops do not typically make decisions at the bypass junctions in ladders, an open question is: is it possible to design microlfuidic ladders that yield significant non-linear transformation of input signal?In this Letter, we study the dynamics of spacing between drop pairs in MLNs with slanted bypasses. We find that because the slant breaks the fore-aft symmetry, it provides significantly more control over drop spacing than symmetric MLNs. We also discover that inclusion ...