Competition of Hastens

Amkraut, Alfred A.; Garvey, James E.; Campbell, Dan H.

doi:10.1084/jem.124.3.293

Cited by 39 publications

(12 citation statements)

References 12 publications

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“…This is suggested by the observation recently reported by Arnkraut et al (18) that, in their systems, competition occurred only when both haptens were on the same carrier molecule. Thus, the results obtained in such comparisons may be dependent upon a variety of variables, e.g., nature of the two haptens, nature of the carrier molecules, degree of substitution, dose of antigens used in immunization, etc.…”

Section: Discussionmentioning

confidence: 54%

Studies on the Control of Antibody Synthesis

Brody

Walker

Siskind

1967

The Journal of Experimental Medicine

106

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In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.

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Section: Discussionmentioning

confidence: 54%

Studies on the Control of Antibody Synthesis

Brody

Walker

Siskind

1967

The Journal of Experimental Medicine

106

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“…R-bovine serum albumin (R-BSA) was prepared as previously described [14], a method which yields a coupling ratio of R24-BSA. Rhesus monkeys were immu nized with 1 mg R-Tyr in complete Freund's adjuvant distributed s. c. in small doses in the lateral areas of the body.…”

Section: Methodsmentioning

confidence: 99%

Antigen Mediated Transformation of Rhesus Lymphocytes in Immediate and Delayed Hypersensitivity

Mackler¹,

Malley²,

Amkraut³

1971

Int Arch Allergy Immunol

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In vitro lymphocyte transformation was demonstrated using peripheral lymphocytes from rhesus monkeys showing either ‘pure’ atopic (Ascaris induced) or ‘pure’ delayed (p-azobenzenearsono-N-acetyl tyrosine induced) hypersensitivity. Lymphocytes from animals immunized by intravenous injection of 2, 4, 6-trinitrophenyl-Keyhole Limpet Hemocyanin (TNP-KLH) did not show transformation either during the active phase of antibody production or at any time thereafter. However, lymphocytes obtained from animals immunized with TNP-KLH in complete Freund’s adjuvant showed transformation not only with TNP-KLH but also with the hapten (TNP) on a heterologous carrier. The relationship of these observations to cell proliferation without MIF production and to the avidity of antigen-cell interaction needed for in vitro transformation is discussed.

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“…Competition phenomena between synthetic antigens (5,6) as well as between hapten conjugates (3,(7)(8)(9)(10)(11)(12) have been reported. Adler (3) showed that the introduction of p-azobenzenearsonate residues into ferritin impaired the formation of anti-ferritin antibodies in mice.…”

Section: (From the Section Of Chemical Immunology The Weizmann Instimentioning

confidence: 99%

“…Adler (3) showed that the introduction of p-azobenzenearsonate residues into ferritin impaired the formation of anti-ferritin antibodies in mice. Amkraut et al (10) found, in rabbits, that immunization with doubly substituted carrier (bovine serum albumin, sheep red cell stroma, or keyhole limpet hemocyanin) enabled the dinitrophenyl groups to suppress the antibody response to p-azobenzenearsonate. Recently Siskind et al (12), who also used these haptens, reported decreased antibody formation in rabbits against both determinants.…”

Section: (From the Section Of Chemical Immunology The Weizmann Instimentioning

confidence: 99%

Antigenic Competition Between Polypeptidyl Determinants in Normal and Tolerant Rabbits

Schechter

1968

The Journal of Experimental Medicine

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Competition between two polypeptidyl determinants was studied in normal rabbits and rabbits made tolerant to the competing antigen. The capacity of poly-DL-phenylalanyl protein conjugate to inhibit the formation of antibodies specific to the poly-DL-alanyl determinant was dependent on the nature of the protein carrier of the singly substituted antigens. Competition occurred only when the peptidyl determinants were attached to identical or similar (RSA and HSA) carriers. Thus, the immune response toward the poly-DL-alanyl determinant was impaired by injecting the pairs p-DL-PheRSA and p-DL-AlaHSA, or p-DL-PheRNase and p-DL-AlaRNase. Suppression of the formation of antibodies with poly-DL-alanyl specificity was not observed, however, upon administration of p-DL-PheRSA together with p-DL-AlaRNase or of p-DL-PheRNase with p-DL-AlaHSA. Tolerance to p-DL-PheRSA was induced by injecting this material into newborn rabbits. The tolerant animals retained their capacity to produce anti-poly-DL-alanyl antibodies upon injection of p-DL-AlaRSA or p-DL-AlaHSA. However, when these poly-DL-alanyl proteins were administered together with p-DL-PheRSA, antibodies against the poly-DL-alanyl determinant were not formed even though no antibodies with poly-DL-phenylalanyl specificity were produced. These results indicate that in competition experiments the preference in the immune response against a given determinant is dependent not only on the nature of the competing determinants, but it is also governed to a large extent by the over-all properties of the antigenic molecules. This suggests that at the stage at which the competition occurs the competing molecules had not undergone considerable degradation. On the basis of experiments with tolerant animals, it is suggested that in normal animals antibody formation to the competing antigen is not the cause of its inhibitory action on the response against the other antigen. The competition experiments described suggest that an antibody-forming cell is multipotent.

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Competition of Hastens

Cited by 39 publications

References 12 publications

Studies on the Control of Antibody Synthesis

Studies on the Control of Antibody Synthesis

Antigen Mediated Transformation of Rhesus Lymphocytes in Immediate and Delayed Hypersensitivity

Antigenic Competition Between Polypeptidyl Determinants in Normal and Tolerant Rabbits

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