Competitive incorporation of Eu(III) and Na(I) ions into citric acid-passivated hydroxyapatite particles

Wanyu, Shi; Kataoka, Takuya; Hashimoto, Takeshi; Liu, Zizhen; Tagaya, Motohiro

doi:10.1016/j.matlet.2021.130561

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…By exploiting the interaction between the ions located at the Ca sites in HAp and the carboxyl ions of the citric acid molecule, the synthesis of hybrid NPs can be achieved. [224][225][226][227][228][229][230] In order to utilize the aforementioned nanomaterial system for specific cell visualization, the authors added citrate ions during the synthetic process for substituting Eu 3+ with the Ca sites of the HAp NPs (Fig. 15(a)).…”

Section: Photofunctionalizationmentioning

confidence: 99%

“…It was also shown that the substitution of different ion species and the control of the citrate coordination environment significantly influenced the photoluminescence properties of the NPs. [224][225][226]228,230 On the other hand, the coordination of citrate ions allowed the reduction of the NP sizes, which enabled applications for the fabrication of transparent HAp films. 227,229,233 3.4.3.…”

Section: Photofunctionalizationmentioning

confidence: 99%

“…By exploiting the interaction between the ions located at the Ca sites in HAp and the carboxyl ions of the citric acid molecule, the synthesis of hybrid NPs can be achieved. 224–230…”

Section: Surface Functionalization Of Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

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Surface functionalization of hydroxyapatite nanoparticles for biomedical applications

Kataoka,

Liu,

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et al. 2024

J. Mater. Chem. B

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Section: Photofunctionalizationmentioning

confidence: 99%

Section: Photofunctionalizationmentioning

confidence: 99%

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Surface functionalization of hydroxyapatite nanoparticles for biomedical applications

Kataoka,

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Yamada

et al. 2024

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Study on occurrence form and solidification mechanism of alkaline components in red mud

Gao,

Li,

Zhang

et al. 2023

J Mater Cycles Waste Manag

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Direct Immobilization of Folic Acid Molecules on Hydroxyapatite Nanoparticles with Substitution and Coordination Phenomena

Shi,

Hatori,

Noda

et al. 2024

ACS Biomater. Sci. Eng.

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We successfully synthesized folic acid (FA) immobilized hydroxyapatite (HA) nanoparticles without using a mediative reagent (e.g., silane coupling agent), and the immobilization states were evaluated and discussed. The HA nanoparticles with higher biocompatibility have two different planes, namely, c- and m-planes. These plane surfaces are rich in phosphate groups (P-site) and Ca2+ ions (C-site), respectively. We suggested that during the synthesis of the HA nanoparticles, the P-site substitution and C-site coordination with the addition of organic molecules containing -COO– ions can occur. Thus, it is possible to simultaneously immobilize two molecules to one HA nanoparticle. In this study, we successfully synthesized FA-immobilized HA nanoparticles by P-site substitution and C-site coordination reactions, which were named as substitution type and coordination type. In the substitution type, when FA was reacted with HA during the nucleation stage, the PO4 3– ions of HA decreased as the FA ratio of coverage surface area increased, and the crystalline phase was changed significantly from the Ca deficient HA to the carbonated HA phase. Accordingly, it was indicated that FA was immobilized on HA by the P-site substitution. In the coordination type, since FA was reacted with HA after the completion of crystal growth, the crystalline phase was changed slightly as the FA ratio of coverage surface area increased, indicating that FA was immobilized on HA by the C-site coordination. From the above, we controlled the FA immobilization states on the HA nanoparticles by the P-site substitution and the C-site coordination through the FA addition timing in the synthesis. Since the -COO– ions in FA could be selectively substituted with the P-site in HA, it is possible to directly coordinate the foreign organic molecules to the Ca2+ ions in HA. Therefore, the immobilization technique of this study is expected to achieve two different drug molecules with diagnosis and therapy functions (i.e., theranostics) on one nanoparticle.

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Competitive incorporation of Eu(III) and Na(I) ions into citric acid-passivated hydroxyapatite particles

Cited by 3 publications

References 23 publications

Surface functionalization of hydroxyapatite nanoparticles for biomedical applications

Surface functionalization of hydroxyapatite nanoparticles for biomedical applications

Study on occurrence form and solidification mechanism of alkaline components in red mud

Direct Immobilization of Folic Acid Molecules on Hydroxyapatite Nanoparticles with Substitution and Coordination Phenomena

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